Parkinson's disease due to the R1441G mutation in Dardarin: A founder effect in the Basques

Javier Simón-Sánchez, José Félix Martí-Massó, José Vicente Sánchez-Mut, Coro Paisán-Ruiz, Angel Martínez-Gil, Javier Ruiz-Martínez, Amets Sáenz, Andrew B. Singleton, Adolfo Lopéz de Munain, Jordi Pérez-Tur

Research output: Contribution to journalArticlepeer-review

75 Scopus citations


The recent discovery of mutations in Dardarin (LRRK2) have been related to the appearance of Parkinson's disease in several families. Notably, one single mutation in this gene (R1441G) not only appeared in familial, but also in apparently sporadic Parkinson disease (PD) patients of Basque descent. A clinical population was ascertained, and subjects were classified into Basque and non-Basque descent according to their known ancestry. The R1441G mutation was assayed using an allele-specific polymerase chain reaction, and several single nucleotide polymorphisms surrounding this mutation were analyzed by direct sequencing. In addition to 22 members of the original Basque families where R1441G was identified, we observed 17 carriers of the mutation who were apparently related through a common ancestor. From a clinical perspective, the disease observed in mutation carriers is indistinguishable from that in noncarriers. The R1441G mutation causes a form of Parkinson's disease that is equivalent to that observed in idiopathic Parkinson's disease. This mutation appears in 16.4% and 4.0% of familial disease sporadic PD in this Basque population, respectively.

Original languageEnglish
Pages (from-to)1954-1959
Number of pages6
JournalMovement Disorders
Issue number11
StatePublished - Nov 2006
Externally publishedYes


  • Basque Country
  • Dardarin
  • Founder effect
  • LRRK2
  • Parkinson's disease


Dive into the research topics of 'Parkinson's disease due to the R1441G mutation in Dardarin: A founder effect in the Basques'. Together they form a unique fingerprint.

Cite this