@article{97256e88b69c46f985ef8b926e647129,
title = "PARIS and SPARTA: Finding the Achilles' Heel of SARS-CoV-2",
abstract = "To understand reinfection rates and correlates of protection for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), we established eight different longitudinal cohorts in 2020 under the umbrella of the PARIS (Protection Associated with Rapid Immunity to SARS-CoV-2)/SPARTA (SARS SeroPrevalence And Respiratory Tract Assessment) studies. Here, we describe the PARIS/SPARTA cohorts, the harmonized assays and analysis that are performed across the cohorts, as well as case definitions for SARS-CoV-2 infection and reinfection that have been established by the team of PARIS/SPARTA investigators. IMPORTANCE Determining reinfection rates and correlates of protection against SARSCoV-2 infection induced by both natural infection and vaccination is of high significance for the prevention and control of coronavirus disease 2019 (COVID-19). Furthermore, understanding reinfections or infection after vaccination and the role immune escape plays in these scenarios will inform the need for updates of the current SARS-CoV-2 vaccines and help update guidelines suitable for the postpandemic world.",
keywords = "COVID-19, SARS-CoV-2, antibodies, cohort study, reinfection",
author = "{PARIS/SPARTA Study Group} and Viviana Simon and Vamsi Kota and Bloomquist, {Ryan F.} and Hanley, {Hannah B.} and David Forgacs and Savita Pahwa and Suresh Pallikkuth and Miller, {Loren G.} and Joanna Schaenman and Yeaman, {Michael R.} and David Manthei and Joshua Wolf and Gaur, {Aditya H.} and Estepp, {Jeremie H.} and Komal Srivastava and Carre{\~n}o, {Juan Manuel} and Frans Cuevas and Ellebedy, {Ali H.} and Aubree Gordon and Riccardo Valdez and Sarah Cobey and Reed, {Elaine F.} and Ravindra Kolhe and Thomas, {Paul G.} and Stacey Schultz-Cherry and Ross, {Ted M.} and Florian Krammer and Klebert, {Michael K.} and {Turner Wooseob}, {Jackson S.} and Kalaidina, {Kim Elizaveta} and Presti, {Rachel M.} and O'Halloran, {Jane A.} and Alem Haile and Goss, {Charles W.} and Rauseo, {Adriana M.} and Aaron Schmitz and Tingting Lei and Erin Williams and Michael Hoffer and Hala Alshammary and Amoako, {Angela A.} and Dalles Andre and Awawda, {Mahmoud H.} and Katherine Beach and Carolina Berm{\'u}dez-Gonz{\'a}lez and Dominika Bielak and Cai, {Gianna Y.} and Giulio Kleiner and Mulder, {Lubbertus C.F.} and Miti Saksena",
note = "Publisher Copyright: Copyright {\textcopyright} 2022 Simon et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.",
year = "2022",
month = jun,
doi = "10.1128/msphere.00179-22",
language = "English",
volume = "7",
journal = "mSphere",
issn = "2379-5042",
publisher = "American Society for Microbiology",
number = "3",
}