Parental decision-making differences between patients in two healthcare systems for choroid plexus cysts

Christina C. Apodaca, Roderick F. Hume,, Wendy J. Evans, Laura S. Martin, Mark I. Evans, Byron C. Calhoun

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Objective: We evaluated the medical-sociological implications of parental perception of risk and decision-making choices for prenatally ascertained choroid plexus cysts (CPCs) between two obstetric populations with similar clinical situations. Methods: The Wayne State University (WSU) Reproductive Genetics database and the Madigan Army Medical Center (MAMC) experience were reviewed to compare the rates of aneuploidy and invasive testing for cases with CPC. Aneuploidy rates were compared between those with isolated CPC, CPC with advanced maternal age (AMA), and CPC associated with multiple anomalies. Results: 186 cases were identified in the WSU cohort, of whom 27 (15%) declined invasive fetal testing. In the remaining 159 cases, aneuploidy was present in 2/132 (1.5%) isolated CPCs, 3/11 (27%) CPCs with AMA, and 15/16 (93%) CPCs with multiple anomalies. 107 cases were identified in the MAMC cohort, of whom 99 (92%) declined invasive fetal testing. No cases of aneuploidy were found in the 3/12 AMA cases or 5/95 non-AMA cases who underwent amniocentesis. Conclusions: The 2 cases of aneuploidy with isolated CPC cannot be ignored, and provide an estimated attributable risk of at least 0.8%, a higher risk than 38 years of age. However, the parental sociologic context may be as important as the genetic-prognostic risk for decision-making. Copyright (C) 2000 S. Karger AG, Basel.

Original languageEnglish
Pages (from-to)338-341
Number of pages4
JournalFetal Diagnosis and Therapy
Volume15
Issue number6
DOIs
StatePublished - 2000
Externally publishedYes

Keywords

  • Choroid plexus cyst
  • Fetal aneuploidy testing
  • Management of fetal malformations
  • Parental decisions

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