TY - JOUR
T1 - Parental chromosomal heteromorphisms are not associated with an increased risk of embryo aneuploidy
AU - Hernandez-Nieto, Carlos
AU - Gayete-Lafuente, Sonia
AU - Alkon-Meadows, Tamar
AU - Lee, Joseph
AU - Luna-Rojas, Martha
AU - Mukherjee, Tanmoy
AU - Copperman, Alan B.
AU - Sandler, Benjamin
N1 - Publisher Copyright:
© 2021, Sociedade Brasileira de Reproducao Assistida. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Objective: Although chromosomal heteromorphisms are commonly found in the general population, some researchers have suggested a correlation with higher rates of embryo aneuploidy. This study aimed to assess the rates of embryo aneuploidy in couples who carry a chromosome heteromorphism. Methods: The study included couples who had G-banding karyotype testing and underwent an IVF/ PGT-A cycle between January 2012 and March 2018. The participants were classified by couple karyotype: Group A: ≥1 patient reported to be a heterochromatic variant carrier; Group B: both partners reported to be “normal”. We assessed the rates of aneuploidy among the groups. We ran a multivariate regression analysis to assess the relationship between heterochromatic variants and the rates of embryo aneuploidy. Results: Of the 946 couples analyzed, 48 (5.0%) reported being a carrier of ≥1 heterochromatic variant. We had 869 IVF/PGT-A cycles included in the analysis (Group A: n=48; Group B: n=82). There were no significant differences in embryo ploidy rates among the groups. The heterochromatic chromosome variant was not associated with increased likelihoods of aneuploidy (OR=1.04, CI:95% 0.85– 1.07; p=0.46). Finally, the gender of the heterochromatic variant carrier had no association with increased likelihood of aneuploidy (OR 1.02, CI 95% 0.81-1.28, p=0.82). Conclusions: Our study showed no association between parental heterochromatic chromosome variants and subsequent embryo aneuploidy rates. Ploidy rates do not appear to be negatively associated with couples when at least one patient is reported to be a carrier of a heterochromatic variant on the karyotype.
AB - Objective: Although chromosomal heteromorphisms are commonly found in the general population, some researchers have suggested a correlation with higher rates of embryo aneuploidy. This study aimed to assess the rates of embryo aneuploidy in couples who carry a chromosome heteromorphism. Methods: The study included couples who had G-banding karyotype testing and underwent an IVF/ PGT-A cycle between January 2012 and March 2018. The participants were classified by couple karyotype: Group A: ≥1 patient reported to be a heterochromatic variant carrier; Group B: both partners reported to be “normal”. We assessed the rates of aneuploidy among the groups. We ran a multivariate regression analysis to assess the relationship between heterochromatic variants and the rates of embryo aneuploidy. Results: Of the 946 couples analyzed, 48 (5.0%) reported being a carrier of ≥1 heterochromatic variant. We had 869 IVF/PGT-A cycles included in the analysis (Group A: n=48; Group B: n=82). There were no significant differences in embryo ploidy rates among the groups. The heterochromatic chromosome variant was not associated with increased likelihoods of aneuploidy (OR=1.04, CI:95% 0.85– 1.07; p=0.46). Finally, the gender of the heterochromatic variant carrier had no association with increased likelihood of aneuploidy (OR 1.02, CI 95% 0.81-1.28, p=0.82). Conclusions: Our study showed no association between parental heterochromatic chromosome variants and subsequent embryo aneuploidy rates. Ploidy rates do not appear to be negatively associated with couples when at least one patient is reported to be a carrier of a heterochromatic variant on the karyotype.
KW - Chromosomal heteromorphisms
KW - Embryo aneuploidy
KW - Heterochromatic variants
KW - In vitro fertilization
KW - Preimplantation genetic testing (PGT)
UR - http://www.scopus.com/inward/record.url?scp=85118097103&partnerID=8YFLogxK
U2 - 10.5935/1518-0557.20210011
DO - 10.5935/1518-0557.20210011
M3 - Article
C2 - 34061485
AN - SCOPUS:85118097103
SN - 1517-5693
VL - 25
SP - 575
EP - 580
JO - Jornal Brasileiro de Reproducao Assistida
JF - Jornal Brasileiro de Reproducao Assistida
IS - 4
ER -