TY - JOUR
T1 - Parental asthma occurrence, exacerbations and risk of attention-deficit/hyperactivity disorder
AU - Liu, Xiaoqin
AU - Dalsgaard, Søren
AU - Munk-Olsen, Trine
AU - Li, Jiong
AU - Wright, Rosalind J.
AU - Momen, Natalie C.
N1 - Funding Information:
Liu X. is supported by the Danish Council for Independent Research (DFF-5053-00156B). Dalsgaard S. and Munk-Olsen T. are supported by iPSYCH, the Lundbeck Foundation Initiative for Integrative Psychiatric Research ( R155-2014-1724 ). Dalsgaard S. is also supported by grants from Aarhus University Research Foundation ( AUFF-E-2015-FLS-8-61 ), The Lundbeck Foundation ( R102-A9118 ), National Institute of Health (R01, grant no ES026993 ), Novo Nordisk Foundation (grant no 22018 ) and the European Commission (Horizon 2020, grant no 667302 ). Momen N. and Li J. are supported by the Nordic Cancer Union (176673, 186200, R217-A13234-18-S65), the Danish Council for Independent Research (DFF-6110-00019B) and Karen Elise Jensens Fond (2016). Li J. is also supported by the National Natural Science Foundation of China ( 81530086 ). During the preparation of this manuscript, Wright R.J. was supported by the National Institutes of Health, UG3 OD23337, and R01 HD082078. The funders had no roles in study design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/11
Y1 - 2019/11
N2 - Objective: To investigate whether intrauterine exposure to maternal asthma or asthma exacerbations increases the risk of attention-deficit/hyperactivity disorder (ADHD). Methods: Using Danish register data, this cohort study comprised of 961,202 live singletons born in Denmark during 1997–2012. Children were followed to a maximum of 20.0 years from birth until the first of ADHD-diagnosis/prescription, emigration, death, or 31 December 2016. Cox regression models were used to evaluate the association between maternal or paternal asthma, asthma exacerbations and offspring ADHD. Results: During 11.4 million person-years of follow-up, 27,780 (2.9%) children were identified as having ADHD. ADHD risk was increased among offspring born to asthmatic mothers (hazard ratio (HR) 1.41, 95% CI: 1.36–1.46) or asthmatic fathers (HR 1.13, 95% CI: 1.08–1.18). Antenatal antiasthma medication treatment did not increase offspring ADHD. However, higher risks were observed among offspring of mothers with asthma exacerbations compared with children of asthmatic mothers with no exacerbations: HR 1.12 (95% CI: 1.00–1.25) for pre-pregnancy exacerbations; 1.21 (95% CI: 1.00–1.47) for exacerbations during pregnancy; and 1.25 (95% CI: 1.08–1.44) for exacerbations after delivery. Conclusions: These results support theories regarding shared genetic and environmental risk factors having a role in the development of ADHD.
AB - Objective: To investigate whether intrauterine exposure to maternal asthma or asthma exacerbations increases the risk of attention-deficit/hyperactivity disorder (ADHD). Methods: Using Danish register data, this cohort study comprised of 961,202 live singletons born in Denmark during 1997–2012. Children were followed to a maximum of 20.0 years from birth until the first of ADHD-diagnosis/prescription, emigration, death, or 31 December 2016. Cox regression models were used to evaluate the association between maternal or paternal asthma, asthma exacerbations and offspring ADHD. Results: During 11.4 million person-years of follow-up, 27,780 (2.9%) children were identified as having ADHD. ADHD risk was increased among offspring born to asthmatic mothers (hazard ratio (HR) 1.41, 95% CI: 1.36–1.46) or asthmatic fathers (HR 1.13, 95% CI: 1.08–1.18). Antenatal antiasthma medication treatment did not increase offspring ADHD. However, higher risks were observed among offspring of mothers with asthma exacerbations compared with children of asthmatic mothers with no exacerbations: HR 1.12 (95% CI: 1.00–1.25) for pre-pregnancy exacerbations; 1.21 (95% CI: 1.00–1.47) for exacerbations during pregnancy; and 1.25 (95% CI: 1.08–1.44) for exacerbations after delivery. Conclusions: These results support theories regarding shared genetic and environmental risk factors having a role in the development of ADHD.
KW - Asthma
KW - Attention-deficit/hyperactivity disorder
KW - Cohort studies
KW - Registries
UR - http://www.scopus.com/inward/record.url?scp=85071971036&partnerID=8YFLogxK
U2 - 10.1016/j.bbi.2019.08.198
DO - 10.1016/j.bbi.2019.08.198
M3 - Article
C2 - 31476415
AN - SCOPUS:85071971036
SN - 0889-1591
VL - 82
SP - 302
EP - 308
JO - Brain, Behavior, and Immunity
JF - Brain, Behavior, and Immunity
ER -