TY - JOUR
T1 - Parental Age and Differential Estimates of Risk for Neuropsychiatric Disorders
T2 - Findings From the Danish Birth Cohort
AU - Janecka, Magdalena
AU - Hansen, Stefan N.
AU - Modabbernia, Amirhossein
AU - Browne, Heidi A.
AU - Buxbaum, Joseph D.
AU - Schendel, Diana E.
AU - Reichenberg, Abraham
AU - Parner, Erik T.
AU - Grice, Dorothy E.
N1 - Funding Information:
This work was supported by the Lundbeck Foundation Initiative for Integrative Psychiatric Research (to D.S.), the National Institutes of Health (grant HD073978 to A.R. and MH097849 to J.D.B.), Mindworks Charitable Lead Trust (to D.E.G.), the Mindich Child Health and Development Institute (to D.E.G. and J.D.B.), the Friedman Brain Institute (to D.E.G.), the Seaver Foundation (to J.D.B., A.R., D.E.G., and M.J.), and the Stanley Center for Psychiatric Research (to D.E.G.). This work was supported by the Lundbeck Foundation Initiative for Integrative Psychiatric Research (to D.S.), the National Institutes of Health (grant HD073978 to A.R. and MH097849 to J.D.B.), Mindworks Charitable Lead Trust (to D.E.G.), the Mindich Child Health and Development Institute (to D.E.G. and J.D.B.), the Friedman Brain Institute (to D.E.G.), the Seaver Foundation (to J.D.B., A.R., D.E.G., and M.J.), and the Stanley Center for Psychiatric Research (to D.E.G.). Disclosure: Drs. Janecka, Hansen, Modabbernia, Browne, Buxbaum, Schendel, Reichenberg, Parner, and Grice report no biomedical financial interests or potential conflicts of interest.
Publisher Copyright:
© 2019 American Academy of Child and Adolescent Psychiatry
PY - 2019/6
Y1 - 2019/6
N2 - Objective: Parental age at birth has been shown to affect the rates of a range of neurodevelopmental disorders, but the understanding of the mechanisms through which it mediates different outcomes is still lacking. A population-based cohort was used to assess differential effects of parental age on estimates of risk across pediatric-onset neuropsychiatric disorders: autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), and Tourette's disorder/chronic tic disorder (TD/CT). Method: The study cohort included all singleton births in Denmark from 1980 through 2007 with full information on parental ages (N = 1,490,745) and was followed through December 31, 2013. Cases of ASD, ADHD, OCD, and TD/CT were identified in the Danish Psychiatric Central Register and the National Patient Register. Associations with parental age were modeled using a stratified Cox regression, allowing for changes in baseline diagnostic rates across time. Results: Younger parental age was significantly associated with increased estimates of risk for ADHD and TD/CT, whereas older parental age was associated with ASD and OCD. Except for OCD, no evidence for differential effects of parental ages on male versus female offspring was observed. Conclusion: This study provides novel evidence for the association between age at parenthood and TD/CT and OCD and for the first time shows in a population-based sample that parental age confers differential risk rates for pediatric-onset psychiatric disorders. These results are consistent with a model of shared and unshared risk architecture for pediatric-onset neuropsychiatric conditions, highlighting unique contributions of maternal and paternal ages.
AB - Objective: Parental age at birth has been shown to affect the rates of a range of neurodevelopmental disorders, but the understanding of the mechanisms through which it mediates different outcomes is still lacking. A population-based cohort was used to assess differential effects of parental age on estimates of risk across pediatric-onset neuropsychiatric disorders: autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), and Tourette's disorder/chronic tic disorder (TD/CT). Method: The study cohort included all singleton births in Denmark from 1980 through 2007 with full information on parental ages (N = 1,490,745) and was followed through December 31, 2013. Cases of ASD, ADHD, OCD, and TD/CT were identified in the Danish Psychiatric Central Register and the National Patient Register. Associations with parental age were modeled using a stratified Cox regression, allowing for changes in baseline diagnostic rates across time. Results: Younger parental age was significantly associated with increased estimates of risk for ADHD and TD/CT, whereas older parental age was associated with ASD and OCD. Except for OCD, no evidence for differential effects of parental ages on male versus female offspring was observed. Conclusion: This study provides novel evidence for the association between age at parenthood and TD/CT and OCD and for the first time shows in a population-based sample that parental age confers differential risk rates for pediatric-onset psychiatric disorders. These results are consistent with a model of shared and unshared risk architecture for pediatric-onset neuropsychiatric conditions, highlighting unique contributions of maternal and paternal ages.
KW - maternal age
KW - neurodevelopmental disorders
KW - parental age
KW - paternal age
KW - psychiatric disorders
UR - http://www.scopus.com/inward/record.url?scp=85066026517&partnerID=8YFLogxK
U2 - 10.1016/j.jaac.2018.09.447
DO - 10.1016/j.jaac.2018.09.447
M3 - Article
C2 - 30825496
AN - SCOPUS:85066026517
SN - 0890-8567
VL - 58
SP - 618
EP - 627
JO - Journal of the American Academy of Child and Adolescent Psychiatry
JF - Journal of the American Academy of Child and Adolescent Psychiatry
IS - 6
ER -