Parathyroid hormone-related protein a peptide of diverse physiologic functions

Anne E. de Papp, Andrew F. Stewart

Research output: Contribution to journalReview articlepeer-review

70 Scopus citations


Parathyroid hormone-related protein (PTHrP) is the factor responsible for the syndrome of humoral hypercalcemia of malignancy. PTHrP is produced by a multitude o f normal as well as malignant cells, and exerts both classic parathyroid hormone (PTH)-like and PTH-unlike effects. The molecular cloning of the PTHrP gene, and the subsequent recognition of its widespread expression in normal tissues under normal physiologic conditions, has prompted intense inquiry into its biologic function. PTHrP appears to act in an autocrine or paracrine fashion in (a) normal embryogenesis and neonatal development, (b) cellular growth and differentiation, (c) reproduction and lactation, (d) epithelial calcium transport, and (e) smooth muscle relaxation. These five key emerging physiologic roles of PTHrP are the focus of this review.

Original languageEnglish
Pages (from-to)181-187
Number of pages7
JournalTrends in Endocrinology and Metabolism
Issue number6
StatePublished - Aug 1993
Externally publishedYes


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