TY - JOUR
T1 - Parathyroid hormone-related peptide - A smooth muscle tone and proliferation regulatory protein
AU - Massfelder, Thierry
AU - Fiaschi-Taesch, Nathalie
AU - Stewart, Andrew Fyfe
AU - Helwig, Jean Jacques
PY - 1998
Y1 - 1998
N2 - Parathyroid hormone-related protein (PTHrP) appears to play crucial roles in the cardiovascular system. Over the past few years it has become apparent that there is more than one receptor recognizing parathyroid hormone or PTHrP, or both, and that PTHrP is not only a potent vasodilator of vascular smooth muscle cell tone, but is also a regulator of vascular smooth muscle cell proliferation and a secretagogue of renin and vasopressin. Investigators in several laboratories have started to query whether PTHrP intervenes in vascular diseases such as hypertension, (re)stenosis- atherosclerosis and endotoxaemia.
AB - Parathyroid hormone-related protein (PTHrP) appears to play crucial roles in the cardiovascular system. Over the past few years it has become apparent that there is more than one receptor recognizing parathyroid hormone or PTHrP, or both, and that PTHrP is not only a potent vasodilator of vascular smooth muscle cell tone, but is also a regulator of vascular smooth muscle cell proliferation and a secretagogue of renin and vasopressin. Investigators in several laboratories have started to query whether PTHrP intervenes in vascular diseases such as hypertension, (re)stenosis- atherosclerosis and endotoxaemia.
UR - http://www.scopus.com/inward/record.url?scp=0031984265&partnerID=8YFLogxK
U2 - 10.1097/00041552-199801000-00005
DO - 10.1097/00041552-199801000-00005
M3 - Review article
C2 - 9442359
AN - SCOPUS:0031984265
SN - 1062-4821
VL - 7
SP - 27
EP - 32
JO - Current Opinion in Nephrology and Hypertension
JF - Current Opinion in Nephrology and Hypertension
IS - 1
ER -