Parathyroid hormone-related peptide

  • A. E. Broadus
  • , W. J. Burtis
  • , K. Ikeda
  • , K. L. Insogna
  • , C. Lu
  • , J. J. Orloff
  • , A. F. Stewart
  • , R. Vasavada
  • , E. C. Weir
  • , M. Mangin

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

Although the exact physiological role of the PTHRP has yet to be defined in any tissue, all of the findings described are compatible with predominantly local (paracrine and/or autocrine) rather than systemic actions. It is presumed that these actions are mediated by unique PTHRP receptors, although these have yet to be demonstrated. If this local regulatory hypothesis proves to be correct, it is quite possible that the only circumstances in which the PTHRP enters the systemic circulation in sufficient quantities to exert a conventional endocrine effect is in the specific pathological setting of the syndrome of humoral hypercalcemia of malignancy. In this circumstance, the PTHRP appears to be interacting (or cross-reacting) with classical PTH receptors.

Original languageEnglish
Title of host publicationCalcium regulation and bone metabolism. Basic and clinical aspects
Subtitle of host publicationproceedings of the 10th International Conference on calcium regulating hormones and bone metabolism. ICS886
EditorsD.V. Cohn, F.H. Glorieux, T.J. Martin, D.V. Cohn, F.H. Glorieux, T.J. Martin
PublisherElsevier Science Publishers B.V.
Pages80-88
Number of pages9
ISBN (Print)0444813292
StatePublished - 1990
Externally publishedYes
EventThe 10th International Conference on calcium regulating hormones and bone metabolism -
Duration: 9 Sep 198914 Sep 1989

Publication series

NameCalcium regulation and bone metabolism. Basic and clinical aspects: proceedings of the 10th International Conference on calcium regulating hormones and bone metabolism. ICS886

Conference

ConferenceThe 10th International Conference on calcium regulating hormones and bone metabolism
Period9/09/8914/09/89

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