TY - JOUR
T1 - ParaPep
T2 - A Web resource for experimentally validated antiparasitic peptide sequences and their structures
AU - Mehta, Divya
AU - Anand, Priya
AU - Kumar, Vineet
AU - Joshi, Anshika
AU - Mathur, Deepika
AU - Singh, Sandeep
AU - Tuknait, Abhishek
AU - Chaudhary, Kumardeep
AU - Gautam, Shailendra K.
AU - Gautam, Ankur
AU - Varshney, Grish C.
AU - Raghava, Gajendra P.S.
N1 - Publisher Copyright:
© The Author(s) 2014.
PY - 2014
Y1 - 2014
N2 - ParaPep is a repository of antiparasitic peptides, which provides comprehensive information related to experimentally validated antiparasitic peptide sequences and their structures. The data were collected and compiled from published research papers, patents and from various databases. The current release of ParaPep holds 863 entries among which 519 are unique peptides. In addition to peptides having natural amino acids, ParaPep also consists of peptides having D-amino acids and chemically modified residues. In ParaPep, most of the peptides have been evaluated for growth inhibition of various species of Plasmodium, Leishmania and Trypanosoma. We have provided comprehensive information about these peptides that include peptide sequence, chemical modifications, stereochemistry, antiparasitic activity, origin, nature of peptide, assay types, type of parasite, mode of action and hemolytic activity. Structures of peptides consisting of natural, as well as modified amino acids have been determined using state-of-the-art software, PEPstr. To facilitate users, various user-friendly web tools, for data fetching, analysis and browsing, have been integrated. We hope that ParaPep will be advantageous in designing therapeutic peptides against parasitic diseases.
AB - ParaPep is a repository of antiparasitic peptides, which provides comprehensive information related to experimentally validated antiparasitic peptide sequences and their structures. The data were collected and compiled from published research papers, patents and from various databases. The current release of ParaPep holds 863 entries among which 519 are unique peptides. In addition to peptides having natural amino acids, ParaPep also consists of peptides having D-amino acids and chemically modified residues. In ParaPep, most of the peptides have been evaluated for growth inhibition of various species of Plasmodium, Leishmania and Trypanosoma. We have provided comprehensive information about these peptides that include peptide sequence, chemical modifications, stereochemistry, antiparasitic activity, origin, nature of peptide, assay types, type of parasite, mode of action and hemolytic activity. Structures of peptides consisting of natural, as well as modified amino acids have been determined using state-of-the-art software, PEPstr. To facilitate users, various user-friendly web tools, for data fetching, analysis and browsing, have been integrated. We hope that ParaPep will be advantageous in designing therapeutic peptides against parasitic diseases.
UR - http://www.scopus.com/inward/record.url?scp=84987679569&partnerID=8YFLogxK
U2 - 10.1093/database/bau051
DO - 10.1093/database/bau051
M3 - Article
C2 - 24923818
AN - SCOPUS:84987679569
SN - 1758-0463
VL - 2014
JO - Database : the journal of biological databases and curation
JF - Database : the journal of biological databases and curation
ER -