TY - JOUR
T1 - Paramyxoviruses from bats
T2 - changes in receptor specificity and their role in host adaptation
AU - Haas, Griffin D.
AU - Lee, Benhur
N1 - Funding Information:
This work is supported in part by National Institutes of Health (USA) R01AI123449 and the Bill and Melinda Gates Foundation Pandemic Antiviral Discovery (PAD) initiative for henipavirus to B.L. G.D.H is supported by the National Science Foundation Graduate Research Fellowship Program under Grant No. 1842169 . Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation. We apologize to any authors whose work could not be included in this article due to space constraints.
Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2023/2
Y1 - 2023/2
N2 - Global metagenomic surveys have revealed that bats host a diverse array of paramyxoviruses, including species from at least five major genera. An essential determinant of successful spillover is the entry of a virus into a new host. We evaluate the role of receptor usage in the zoonotic potential of bat-borne henipaviruses, morbilliviruses, pararubulaviruses, orthorubulaviruses, and jeilongviruses; successful spillover into humans depends upon compatibility of a respective viral attachment protein with its cognate receptor. We also emphasize the importance of postentry restrictions in preventing spillover. Metagenomics and characterization of newly identified paramyxoviruses have greatly improved our understanding of spillover determinants, allowing for better forecasts of which bat-borne viruses may pose the greatest risk for cross-species transmission into humans.
AB - Global metagenomic surveys have revealed that bats host a diverse array of paramyxoviruses, including species from at least five major genera. An essential determinant of successful spillover is the entry of a virus into a new host. We evaluate the role of receptor usage in the zoonotic potential of bat-borne henipaviruses, morbilliviruses, pararubulaviruses, orthorubulaviruses, and jeilongviruses; successful spillover into humans depends upon compatibility of a respective viral attachment protein with its cognate receptor. We also emphasize the importance of postentry restrictions in preventing spillover. Metagenomics and characterization of newly identified paramyxoviruses have greatly improved our understanding of spillover determinants, allowing for better forecasts of which bat-borne viruses may pose the greatest risk for cross-species transmission into humans.
UR - http://www.scopus.com/inward/record.url?scp=85143729816&partnerID=8YFLogxK
U2 - 10.1016/j.coviro.2022.101292
DO - 10.1016/j.coviro.2022.101292
M3 - Review article
AN - SCOPUS:85143729816
SN - 1879-6257
VL - 58
JO - Current Opinion in Virology
JF - Current Opinion in Virology
M1 - 101292
ER -