Parameters Associated with Mandibular Osteoradionecrosis

William M. Mendenhall; Carlos Suárez; Eric M. Genden; Remco De Bree; Primož Strojan; Johannes A. Langendijk; Mäkitie M.A. Antti; Robert Smee; Avraham Eisbruch; Anne W.M. Lee; Alessandra Rinaldo; Alfio Ferlito

doi:10.1097/COC.0000000000000424

Parameters Associated with Mandibular Osteoradionecrosis

William M. Mendenhall, Carlos Suárez, Eric M. Genden, Remco De Bree, Primož Strojan, Johannes A. Langendijk, Mäkitie M.A. Antti, Robert Smee, Avraham Eisbruch, Anne W.M. Lee, Alessandra Rinaldo, Alfio Ferlito

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

The objective of this review is to discuss factors related to the risk of osteoradionecrosis (ORN) and how to minimize the likelihood of this complication. A PubMed search for publications pertaining to ORN within the last 3 years was conducted revealing 44 publications. The bibliographies of these publications were reviewed to identify additional references spanning a longer time period. The incidence of ORN is 5% to 10% with a median latency period of 1 to 2 years or less. The likelihood of ORN depends on a number of factors including primary site and extent of disease, dental status, treatment modality, radiotherapy (RT) dose, volume of mandible included in the planning target volume, RT fractionation schedule and technique, and teeth extractions. The risk of ORN may be reduced by limiting the RT dose and volume of mandible irradiated without increasing the risk of a local-regional recurrence due to a marginal miss.

Original language	English
Pages (from-to)	1276-1280
Number of pages	5
Journal	American Journal of Clinical Oncology: Cancer Clinical Trials
Volume	41
Issue number	12
DOIs	https://doi.org/10.1097/COC.0000000000000424
State	Published - 1 Dec 2018

Keywords

head and neck cancer
mandible
mandibular osteoradionecrosis
radiotherapy
teeth extraction

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title = "Parameters Associated with Mandibular Osteoradionecrosis",

abstract = "The objective of this review is to discuss factors related to the risk of osteoradionecrosis (ORN) and how to minimize the likelihood of this complication. A PubMed search for publications pertaining to ORN within the last 3 years was conducted revealing 44 publications. The bibliographies of these publications were reviewed to identify additional references spanning a longer time period. The incidence of ORN is 5% to 10% with a median latency period of 1 to 2 years or less. The likelihood of ORN depends on a number of factors including primary site and extent of disease, dental status, treatment modality, radiotherapy (RT) dose, volume of mandible included in the planning target volume, RT fractionation schedule and technique, and teeth extractions. The risk of ORN may be reduced by limiting the RT dose and volume of mandible irradiated without increasing the risk of a local-regional recurrence due to a marginal miss.",

keywords = "head and neck cancer, mandible, mandibular osteoradionecrosis, radiotherapy, teeth extraction",

author = "Mendenhall, {William M.} and Carlos Su{\'a}rez and Genden, {Eric M.} and Bree, {Remco De} and Primo{\v z} Strojan and Langendijk, {Johannes A.} and Antti, {M{\"a}kitie M.A.} and Robert Smee and Avraham Eisbruch and Lee, {Anne W.M.} and Alessandra Rinaldo and Alfio Ferlito",

year = "2018",

month = dec,

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doi = "10.1097/COC.0000000000000424",

language = "English",

volume = "41",

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T1 - Parameters Associated with Mandibular Osteoradionecrosis

AU - Mendenhall, William M.

AU - Suárez, Carlos

AU - Genden, Eric M.

AU - Bree, Remco De

AU - Strojan, Primož

AU - Langendijk, Johannes A.

AU - Antti, Mäkitie M.A.

AU - Smee, Robert

AU - Eisbruch, Avraham

AU - Lee, Anne W.M.

AU - Rinaldo, Alessandra

AU - Ferlito, Alfio

PY - 2018/12/1

Y1 - 2018/12/1

N2 - The objective of this review is to discuss factors related to the risk of osteoradionecrosis (ORN) and how to minimize the likelihood of this complication. A PubMed search for publications pertaining to ORN within the last 3 years was conducted revealing 44 publications. The bibliographies of these publications were reviewed to identify additional references spanning a longer time period. The incidence of ORN is 5% to 10% with a median latency period of 1 to 2 years or less. The likelihood of ORN depends on a number of factors including primary site and extent of disease, dental status, treatment modality, radiotherapy (RT) dose, volume of mandible included in the planning target volume, RT fractionation schedule and technique, and teeth extractions. The risk of ORN may be reduced by limiting the RT dose and volume of mandible irradiated without increasing the risk of a local-regional recurrence due to a marginal miss.

AB - The objective of this review is to discuss factors related to the risk of osteoradionecrosis (ORN) and how to minimize the likelihood of this complication. A PubMed search for publications pertaining to ORN within the last 3 years was conducted revealing 44 publications. The bibliographies of these publications were reviewed to identify additional references spanning a longer time period. The incidence of ORN is 5% to 10% with a median latency period of 1 to 2 years or less. The likelihood of ORN depends on a number of factors including primary site and extent of disease, dental status, treatment modality, radiotherapy (RT) dose, volume of mandible included in the planning target volume, RT fractionation schedule and technique, and teeth extractions. The risk of ORN may be reduced by limiting the RT dose and volume of mandible irradiated without increasing the risk of a local-regional recurrence due to a marginal miss.

KW - head and neck cancer

KW - mandible

KW - mandibular osteoradionecrosis

KW - radiotherapy

KW - teeth extraction

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JO - American Journal of Clinical Oncology: Cancer Clinical Trials

JF - American Journal of Clinical Oncology: Cancer Clinical Trials

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ER -

Parameters Associated with Mandibular Osteoradionecrosis

Abstract

Keywords

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