TY - JOUR
T1 - Parafoveal scotoma progression in glaucoma
T2 - Humphrey 10-2 versus 24-2 visual field analysis
AU - Park, Sung Chul
AU - Kung, Yungtai
AU - Su, Daniel
AU - Simonson, Joseph L.
AU - Furlanetto, Rafael L.
AU - Liebmann, Jeffrey M.
AU - Ritch, Robert
N1 - Funding Information:
Supported by the John and Dorothy Roberts Research Fund of the New York Glaucoma Research Institute , New York, New York, and the James Cox Chambers Research Fund of the New York Eye and Ear Infirmary , New York, New York (R.F.). Dr. Park is the Peter Crowley Research Scientist at the New York Eye and Ear Infirmary, New York, New York.
PY - 2013/8
Y1 - 2013/8
N2 - Objective: To compare the performance of 10-2 versus 24-2 visual fields (VFs) in detecting progression of initial parafoveal scotoma (IPFS) in glaucomatous eyes. Design: Retrospective, observational study. Participants: Glaucoma patients with the following criteria: (1) an IPFS (≥3 adjacent points with P<0.05 within the central 10 degrees of fixation, 1 point or more with P<0.01 lying at the innermost paracentral points, and no scotoma outside the central 10) in either hemifield based on 2 reliable Humphrey 24-2 Swedish interactive threshold algorithm standard VFs, and (2) 5 or more 10-2 and 24-2 VFs. Methods: Based on threshold map sensitivities, VF progression, defined as having 1 or more significantly progressing point(s) with a slope of sensitivity of less than -1.0 dB/year at P<0.01, was evaluated using pointwise linear regression. Main Outcome Measures: The number of progressing eyes in 10-2 and 24-2 VF analyses. Results: Fifty eyes (50 patients) were included (mean age ± standard deviation, 62±9 years). Mean follow-up period (5.7 vs. 5.6 years) and number of VFs (7.6 vs. 7.8) were similar between 10-2 and 24-2 analyses (all P>0.3). Significantly more progressing eyes were detected in 10-2 than in 24-2 analyses (24 vs. 11 eyes; P = 0.007). This difference became greater within the central 10 (24 vs. 4 eyes; P<0.001). Four of the 11 progressing eyes in 24-2 analysis were missed in 10-2 analysis, whereas 17 of the 24 progressing eyes in 10-2 analysis were missed in 24-2 analysis. The 4 progressing eyes missed in 10-2 analysis had progressing point(s) only outside the central 10 in 24-2 analysis. The other 3 eyes with progressing point(s) only outside the central 10 in 24-2 analysis were detected as progressing in 10-2 analysis. Similar results were obtained when more stringent criteria (at least 2 significantly progressing points within the same hemifield) were used for VF progression. Conclusions: The 10-2 VF detects more progressing eyes than the 24-2 VF in glaucoma patients with IPFS, suggesting that closer surveillance of the central VF using testing algorithms with closely spaced grids is warranted in eyes with parafoveal scotomas.
AB - Objective: To compare the performance of 10-2 versus 24-2 visual fields (VFs) in detecting progression of initial parafoveal scotoma (IPFS) in glaucomatous eyes. Design: Retrospective, observational study. Participants: Glaucoma patients with the following criteria: (1) an IPFS (≥3 adjacent points with P<0.05 within the central 10 degrees of fixation, 1 point or more with P<0.01 lying at the innermost paracentral points, and no scotoma outside the central 10) in either hemifield based on 2 reliable Humphrey 24-2 Swedish interactive threshold algorithm standard VFs, and (2) 5 or more 10-2 and 24-2 VFs. Methods: Based on threshold map sensitivities, VF progression, defined as having 1 or more significantly progressing point(s) with a slope of sensitivity of less than -1.0 dB/year at P<0.01, was evaluated using pointwise linear regression. Main Outcome Measures: The number of progressing eyes in 10-2 and 24-2 VF analyses. Results: Fifty eyes (50 patients) were included (mean age ± standard deviation, 62±9 years). Mean follow-up period (5.7 vs. 5.6 years) and number of VFs (7.6 vs. 7.8) were similar between 10-2 and 24-2 analyses (all P>0.3). Significantly more progressing eyes were detected in 10-2 than in 24-2 analyses (24 vs. 11 eyes; P = 0.007). This difference became greater within the central 10 (24 vs. 4 eyes; P<0.001). Four of the 11 progressing eyes in 24-2 analysis were missed in 10-2 analysis, whereas 17 of the 24 progressing eyes in 10-2 analysis were missed in 24-2 analysis. The 4 progressing eyes missed in 10-2 analysis had progressing point(s) only outside the central 10 in 24-2 analysis. The other 3 eyes with progressing point(s) only outside the central 10 in 24-2 analysis were detected as progressing in 10-2 analysis. Similar results were obtained when more stringent criteria (at least 2 significantly progressing points within the same hemifield) were used for VF progression. Conclusions: The 10-2 VF detects more progressing eyes than the 24-2 VF in glaucoma patients with IPFS, suggesting that closer surveillance of the central VF using testing algorithms with closely spaced grids is warranted in eyes with parafoveal scotomas.
UR - https://www.scopus.com/pages/publications/84881151186
U2 - 10.1016/j.ophtha.2013.01.045
DO - 10.1016/j.ophtha.2013.01.045
M3 - Article
C2 - 23697959
AN - SCOPUS:84881151186
SN - 0161-6420
VL - 120
SP - 1546
EP - 1550
JO - Ophthalmology
JF - Ophthalmology
IS - 8
ER -