TY - JOUR
T1 - Parafoveal nonperfusion analysis in diabetic retinopathy using optical coherence tomography angiography
AU - Krawitz, Brian D.
AU - Phillips, Erika
AU - Bavier, Richard D.
AU - Mo, Shelley
AU - Carroll, Joseph
AU - Rosen, Richard B.
AU - Chui, Toco Y.P.
N1 - Funding Information:
Grant Information: Supported by the National Eye Institute of the National Institutes of Health under award numbers R01EY027301, R01EY024969, and P30EY001931. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Additional funding for this research was provided by the New York Eye and Ear Infirmary Foundation Grant, the Marrus Family Foundation, and the Geraldine Violett Foundation. The sponsors and funding organizations had no role in the design or conduct of this research.
Publisher Copyright:
© 2018 The Authors.
PY - 2018/7
Y1 - 2018/7
N2 - Purpose: To describe a new technique for mapping parafoveal intercapillary areas (PICAs) using optical coherence tomography angiography (OCTA), and demonstrate its utility for quantifying parafoveal nonperfusion in diabetic retinopathy (DR). Methods: Nineteen controls, 15 diabetics with no retinopathy (noDR), 15 with nonproliferative diabetic retinopathy (NPDR), and 15 with proliferative diabetic retinopathy (PDR) were imaged with 10 macular OCTA scans. PICAs were automatically delineated on the averaged superficial OCTA images. Following creation of an eccentricity-specific reference database from the controls, all PICAs greater than 2 SD above the reference means for PICA area and minor axis length were identified as nonperfused areas. Regions of interest (ROI) at 300 lm and 1000 lm from the foveal avascular zone (FAZ) margin were analyzed. Percent nonperfused area was defined as summed nonperfused areas divided by ROI area. Values were compared using Kruskal-Wallis and post-hoc Mann-Whitney U tests. Results: Median values for total percent nonperfused area at the 300-lm ROI were 2.09, 2.44, 18.08, and 27.55 in the control, noDR, NPDR, and PDR groups, respectively. Median values at the 1000-lm ROI were 3.10, 3.31, 13.42, and 23.00. While there were no significant differences between the control and noDR groups, significant differences were observed between all other groups at both ROIs. Conclusions: Percent nonperfused area can quantify parafoveal nonperfusion in DR and can be calculated through automatic delineation of PICAs in an eccentricity-specific manner using a standard deviation mapping approach. Translational Relevance: Percent nonperfused area shows promise as a metric to measure disease severity in diabetic retinopathy.
AB - Purpose: To describe a new technique for mapping parafoveal intercapillary areas (PICAs) using optical coherence tomography angiography (OCTA), and demonstrate its utility for quantifying parafoveal nonperfusion in diabetic retinopathy (DR). Methods: Nineteen controls, 15 diabetics with no retinopathy (noDR), 15 with nonproliferative diabetic retinopathy (NPDR), and 15 with proliferative diabetic retinopathy (PDR) were imaged with 10 macular OCTA scans. PICAs were automatically delineated on the averaged superficial OCTA images. Following creation of an eccentricity-specific reference database from the controls, all PICAs greater than 2 SD above the reference means for PICA area and minor axis length were identified as nonperfused areas. Regions of interest (ROI) at 300 lm and 1000 lm from the foveal avascular zone (FAZ) margin were analyzed. Percent nonperfused area was defined as summed nonperfused areas divided by ROI area. Values were compared using Kruskal-Wallis and post-hoc Mann-Whitney U tests. Results: Median values for total percent nonperfused area at the 300-lm ROI were 2.09, 2.44, 18.08, and 27.55 in the control, noDR, NPDR, and PDR groups, respectively. Median values at the 1000-lm ROI were 3.10, 3.31, 13.42, and 23.00. While there were no significant differences between the control and noDR groups, significant differences were observed between all other groups at both ROIs. Conclusions: Percent nonperfused area can quantify parafoveal nonperfusion in DR and can be calculated through automatic delineation of PICAs in an eccentricity-specific manner using a standard deviation mapping approach. Translational Relevance: Percent nonperfused area shows promise as a metric to measure disease severity in diabetic retinopathy.
KW - Diabetic retinopathy
KW - Intercapillary areas
KW - Nonperfusion
KW - Optical coherence tomography angiography
UR - http://www.scopus.com/inward/record.url?scp=85050486177&partnerID=8YFLogxK
U2 - 10.1167/tvst.7.4.4
DO - 10.1167/tvst.7.4.4
M3 - Article
AN - SCOPUS:85050486177
SN - 2164-2591
VL - 7
JO - Translational Vision Science and Technology
JF - Translational Vision Science and Technology
IS - 4
M1 - 4
ER -