Paracrine WNT5A signaling in healthy and neoplastic mammary tissue

David Kusner; Nicholas Borcherding; Weizhou Zhang

doi:10.1080/23723556.2015.1040145

Paracrine WNT5A signaling in healthy and neoplastic mammary tissue

David Kusner, Nicholas Borcherding, Weizhou Zhang

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Paracrine signaling between mammary epithelial cells has long been appreciated. Recently, we found that Wnt5a, a novel noncanonical Wnt ligand of luminal origin, counteracts canonical Wnt signaling in basal mammary epithelial cells through a paracrine pathway, inhibits the expansion of Erbb2-induced tumor-initiating cells, and suppresses tumor incidence and metastasis.

Original language	English
Article number	e1040145
Journal	Molecular and Cellular Oncology
Volume	3
Issue number	1
DOIs	https://doi.org/10.1080/23723556.2015.1040145
State	Published - 2 Jan 2016
Externally published	Yes

Keywords

Breast cancer
Noncanonical WNT
WNT5A signaling
mammary development

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10.1080/23723556.2015.1040145

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title = "Paracrine WNT5A signaling in healthy and neoplastic mammary tissue",

abstract = "Paracrine signaling between mammary epithelial cells has long been appreciated. Recently, we found that Wnt5a, a novel noncanonical Wnt ligand of luminal origin, counteracts canonical Wnt signaling in basal mammary epithelial cells through a paracrine pathway, inhibits the expansion of Erbb2-induced tumor-initiating cells, and suppresses tumor incidence and metastasis.",

keywords = "Breast cancer, Noncanonical WNT, WNT5A signaling, mammary development",

author = "David Kusner and Nicholas Borcherding and Weizhou Zhang",

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AU - Borcherding, Nicholas

AU - Zhang, Weizhou

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AB - Paracrine signaling between mammary epithelial cells has long been appreciated. Recently, we found that Wnt5a, a novel noncanonical Wnt ligand of luminal origin, counteracts canonical Wnt signaling in basal mammary epithelial cells through a paracrine pathway, inhibits the expansion of Erbb2-induced tumor-initiating cells, and suppresses tumor incidence and metastasis.

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KW - WNT5A signaling

KW - mammary development

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Paracrine WNT5A signaling in healthy and neoplastic mammary tissue

Abstract

Keywords

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