Paracrine WNT5A signaling in healthy and neoplastic mammary tissue

David Kusner, Nicholas Borcherding, Weizhou Zhang

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Paracrine signaling between mammary epithelial cells has long been appreciated. Recently, we found that Wnt5a, a novel noncanonical Wnt ligand of luminal origin, counteracts canonical Wnt signaling in basal mammary epithelial cells through a paracrine pathway, inhibits the expansion of Erbb2-induced tumor-initiating cells, and suppresses tumor incidence and metastasis.

Original languageEnglish
Article numbere1040145
JournalMolecular and Cellular Oncology
Issue number1
StatePublished - 2 Jan 2016
Externally publishedYes


  • Breast cancer
  • Noncanonical WNT
  • WNT5A signaling
  • mammary development


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