Papel de la genética en la leucemia mieloide aguda

Translated title of the contribution: Importance of genetics in acute myeloid leukemia

R. Pippa, M. D. Odero

Research output: Contribution to journalReview articlepeer-review

Abstract

Acute myeloid leukemia (AML) comprises a biologically and clinically heterogeneous group of aggressive disorders that occur as a consequence of a wide variety of genetic and epigenetic abnormalities in hematopoietic progenitors. Despite significant advances in the understanding of the biology of AML, most patients will die from relapsed disease. Whole-genome studies have identified novel recurrent gene mutations with prognostic impact in AML; furthermore, it is likely that in the near future genome-wide sequencing will become a routine for newly diagnosed patients with AML. Therefore, future clinical trials should aim to identify genetically defined high-risk patients, and further research is necessary to identify effective agents and develop new individualized therapeutic strategies for the treatment of this deadly disease.

Translated title of the contributionImportance of genetics in acute myeloid leukemia
Original languageSpanish
Pages (from-to)429-434
Number of pages6
JournalAnales del Sistema Sanitario de Navarra
Volume37
Issue number3
DOIs
StatePublished - 2014
Externally publishedYes

Keywords

  • Acute myeloid leukemia
  • Genetic marker
  • Mutation
  • Prognosis
  • Whole-genome sequencing

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