Paneth cell-like metaplasia of the prostate gland

C. P. Frydman, I. J. Bleiweiss, P. D. Unger, R. E. Gordon, N. V. Brazenas

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


We report two cases of Paneth cell-like metaplasia of the prostate gland, one in poorly differentiated carcinoma and the second in benign hyperplasia. By light microscopy, the Paneth-like cells were indistinguishable from Paneth cells found in the normal small intestine and ultrastructurally showed electron-dense granules typical of Paneth cells. Immunohistochemical stains were positive for prostate-specific antigen and prostatic acid phosphatase and negative for lysozyme and α1-antitrypsin. The clinical significance of Paneth cell-like metaplasia is unknown and may represent an example of the multipotential metaplastic capability of actively dividing cells.

Original languageEnglish
Pages (from-to)274-276
Number of pages3
JournalArchives of Pathology and Laboratory Medicine
Issue number3
StatePublished - 1992
Externally publishedYes


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