TY - JOUR
T1 - Pandemic 2009 H1N1 vaccine protects against 1918 Spanish influenza virus
AU - Medina, Rafael A.
AU - Manicassamy, Balaji
AU - Stertz, Silke
AU - Seibert, Christopher W.
AU - Hai, Rong
AU - Belshe, Robert B.
AU - Frey, Sharon E.
AU - Basler, Christopher F.
AU - Palese, Peter
AU - Garcí-Sastre, Adolfo
N1 - Funding Information:
We thank Benjamin Hale for helpful comments on the paper and Richard Cadagan and Osman Lizardo for excellent technical assistance. We thank the BSL3 Facility Director Simon Daefler and Manager Soo Shin for facilitating experiments conducted under biocontainment. We are grateful to the Hybridoma Shared Research facility at Mount Sinai School of Medicine, New York, for assistance in the generation of the mAbs used in this study. This work was partially supported by a National Institute of Allergy and Infectious Disease (NIAID) Program Project grant (P01AI058113) to A.G.S, C.B and P.P.; by CRIP, an NIAID-funded Centre for Research in Influenza Pathogenesis contract (HHSN266200700010C), to A.G.S and P.P. and a contract (HHSN272200800003C) to R.B.B., all from the National Institutes of Health. S.S. is supported by a fellowship from the German Research Foundation.
PY - 2010
Y1 - 2010
N2 - The 1918 influenza A virus caused the most devastating pandemic, killing approximately 50 million people worldwide. Immunization with 1918-like and classical swine H1N1 virus vaccines results in cross-protective antibodies against the 2009 H1N1 pandemic influenza, indicating antigenic similarities among these viruses. In this study, we demonstrate that vaccination with the 2009 pandemic H1N1 vaccine elicits 1918 virus cross-protective antibodies in mice and humans, and that vaccination or passive transfer of human-positive sera reduced morbidity and conferred full protection from lethal challenge with the 1918 virus in mice. The spread of the 2009 H1N1 influenza virus in the population worldwide, in addition to the large number of individuals already vaccinated, suggests that a large proportion of the population now have cross-protective antibodies against the 1918 virus, greatly alleviating concerns and fears regarding the accidental exposure/release of the 1918 virus from the laboratory and the use of the virus as a bioterrorist agent.
AB - The 1918 influenza A virus caused the most devastating pandemic, killing approximately 50 million people worldwide. Immunization with 1918-like and classical swine H1N1 virus vaccines results in cross-protective antibodies against the 2009 H1N1 pandemic influenza, indicating antigenic similarities among these viruses. In this study, we demonstrate that vaccination with the 2009 pandemic H1N1 vaccine elicits 1918 virus cross-protective antibodies in mice and humans, and that vaccination or passive transfer of human-positive sera reduced morbidity and conferred full protection from lethal challenge with the 1918 virus in mice. The spread of the 2009 H1N1 influenza virus in the population worldwide, in addition to the large number of individuals already vaccinated, suggests that a large proportion of the population now have cross-protective antibodies against the 1918 virus, greatly alleviating concerns and fears regarding the accidental exposure/release of the 1918 virus from the laboratory and the use of the virus as a bioterrorist agent.
UR - http://www.scopus.com/inward/record.url?scp=84870967038&partnerID=8YFLogxK
U2 - 10.1038/ncomms1026
DO - 10.1038/ncomms1026
M3 - Article
C2 - 20975689
AN - SCOPUS:84870967038
SN - 2041-1723
VL - 1
JO - Nature Communications
JF - Nature Communications
IS - 3
M1 - 28
ER -