Pancreatic transplantation at the University of Pittsburgh.

Ngoc L. Thai, Kareem Abu-Elmagd, Akhar Khan, Geoffrey Bond, Amit Basu, Kusum Tom, George Mazariegos, Rakesh Sindhi, Jorge Reyes, Henkie P. Tan, Amadeo Marcos, Thomas E. Starzl, Ron Shapiro

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Campath-1H preconditioning with tacrolimus monotherapy is an effective immunosuppressive regimen for pancreas transplantation, with acceptable patient and graft survival rates early after transplantation. Rejection rates are low under this protocol if the tacrolimus level is kept consistently >10 ng/ml. This immunosuppressive protocol, combined with recent technical refinements, has resulted in lower rates of thrombosis and overall complications. Pancreatic transplantation en-bloc with visceral grafts has the following unique features: Diabetes is a rare indication, and HLA matching is not required. The gland is immunologically protected by the simultaneously transplanted visceral organs. Disease gravity, surgical complexity and gut alloimmunity influence the overall pancreatic allograft survival. The current UNOS listing criteria and data registry should be modified for obvious logistic and scientific reasons.

Original languageEnglish
Pages (from-to)205-214
Number of pages10
JournalClinical transplants
StatePublished - 2004
Externally publishedYes

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