Pancreatic A and B cell stimulation in euthermic and hibernating marmots (Marmota flaviventris): effects of glucose and arginine administration

Gregory L. Florant, Robert Hoo-Paris, Christian Castex, William A. Bauman, B. Ch Sutter

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

In euthermic and hibernating marmots (Marmota flaviventris), the pancreatic A and B cells respond in the appropriate secretory manner to glucose or arginine injection. Although reduced, this response, is clearly present in hibernating marmots. When glucose is administered to euthermic or hibernating marmots, plasma insulin concentrations rise and glucagon levels fall. While similar results are obtained in hibernation, the time period of the response is much longer due to the slowing of temperature dependent metabolic processes. Injection of l-arginine stimulates an increase in plasma glucose, insulin, and glucagon as expected. Measurements of plasma glucose, insulin, and glucagon under basal conditions, suggest that there are no significant differences between any phase of hibernation (eg. entrance, deep hibernation, arousal) and euthermia. These results provide indirect evidence that the pancreatic A and B cells of hibernating marmots continue to function in order to help regulate plasma glucose concentration.

Original languageEnglish
Pages (from-to)309-314
Number of pages6
JournalJournal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology
Volume156
Issue number3
DOIs
StatePublished - May 1986
Externally publishedYes

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