Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination

The Human Immunology Project Consortium (HIPC)

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


Several studies have shown that the pre-vaccination immune state is associated with the antibody response to vaccination. However, the generalizability and mechanisms that underlie this association remain poorly defined. Here, we sought to identify a common pre-vaccination signature and mechanisms that could predict the immune response across 13 different vaccines. Analysis of blood transcriptional profiles across studies revealed three distinct pre-vaccination endotypes, characterized by the differential expression of genes associated with a pro-inflammatory response, cell proliferation, and metabolism alterations. Importantly, individuals whose pre-vaccination endotype was enriched in pro-inflammatory response genes known to be downstream of nuclear factor-kappa B showed significantly higher serum antibody responses 1 month after vaccination. This pro-inflammatory pre-vaccination endotype showed gene expression characteristic of the innate activation state triggered by Toll-like receptor ligands or adjuvants. These results demonstrate that wide variations in the transcriptional state of the immune system in humans can be a key determinant of responsiveness to vaccination.

Original languageEnglish
Pages (from-to)1777-1787
Number of pages11
JournalNature Immunology
Issue number12
StatePublished - Dec 2022


Dive into the research topics of 'Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination'. Together they form a unique fingerprint.

Cite this