@article{9d3aa193fd8340399b8debf1256199bc,
title = "Pan-cancer analysis of post-translational modifications reveals shared patterns of protein regulation",
abstract = "Post-translational modifications (PTMs) play key roles in regulating cell signaling and physiology in both normal and cancer cells. Advances in mass spectrometry enable high-throughput, accurate, and sensitive measurement of PTM levels to better understand their role, prevalence, and crosstalk. Here, we analyze the largest collection of proteogenomics data from 1,110 patients with PTM profiles across 11 cancer types (10 from the National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium [CPTAC]). Our study reveals pan-cancer patterns of changes in protein acetylation and phosphorylation involved in hallmark cancer processes. These patterns revealed subsets of tumors, from different cancer types, including those with dysregulated DNA repair driven by phosphorylation, altered metabolic regulation associated with immune response driven by acetylation, affected kinase specificity by crosstalk between acetylation and phosphorylation, and modified histone regulation. Overall, this resource highlights the rich biology governed by PTMs and exposes potential new therapeutic avenues.",
keywords = "CPTAC, DNA damage response, genomics, mass spectrometry, metabolism, pan-cancer, post-translational modifications, proteomics, transcriptomics",
author = "{Clinical Proteomic Tumor Analysis Consortium} and Yifat Geffen and Shankara Anand and Yo Akiyama and Yaron, {Tomer M.} and Yizhe Song and Johnson, {Jared L.} and Akshay Govindan and {\"O}zg{\"u}n Babur and Yize Li and Emily Huntsman and Wang, {Liang Bo} and Chet Birger and Heiman, {David I.} and Qing Zhang and Mendy Miller and Maruvka, {Yosef E.} and Haradhvala, {Nicholas J.} and Anna Calinawan and Saveliy Belkin and Alexander Kerelsky and Clauser, {Karl R.} and Karsten Krug and Shankha Satpathy and Payne, {Samuel H.} and Mani, {D. R.} and Gillette, {Michael A.} and Dhanasekaran, {Saravana M.} and Mathangi Thiagarajan and Mehdi Mesri and Henry Rodriguez and Robles, {Ana I.} and Carr, {Steven A.} and Lazar, {Alexander J.} and Fran{\c c}ois Aguet and Cantley, {Lewis C.} and Li Ding and Gad Getz and Eunkyung An and Meenakshi Anurag and Jasmin Bavarva and Birrer, {Michael J.} and Song Cao and Michele Ceccarelli and Chan, {Daniel W.} and Chinnaiyan, {Arul M.} and Shrabanti Chowdhury and G{\"u}m{\"u}{\c s}, {Zeynep H.} and Francesca Petralia and Boris Reva and Pei Wang",
note = "Publisher Copyright: {\textcopyright} 2023 The Authors",
year = "2023",
month = aug,
day = "31",
doi = "10.1016/j.cell.2023.07.013",
language = "English",
volume = "186",
pages = "3945--3967.e26",
journal = "Cell",
issn = "0092-8674",
publisher = "Elsevier B.V.",
number = "18",
}