Palmitoleate reverses high fat-induced proinflammatory macrophage polarization via AMP-activated protein kinase (AMPK)

Kenny L. Chan; Nicolas J. Pillon; Darshan M. Sivaloganathan; Sheila R. Costford; Zhi Liu; Marine Théret; Benedicte Chazaud; Amira Klip

doi:10.1074/jbc.M115.646992

Palmitoleate reverses high fat-induced proinflammatory macrophage polarization via AMP-activated protein kinase (AMPK)

Kenny L. Chan
, Nicolas J. Pillon
, Darshan M. Sivaloganathan
, Sheila R. Costford
, Zhi Liu
, Marine Théret
, Benedicte Chazaud
, Amira Klip

Research output: Contribution to journal › Article › peer-review

174 Scopus citations

Abstract

Background: Elevated saturated fats during obesity activate proinflammatory pathways in macrophages, contributing to insulin resistance. Results: The monounsaturated fatty acid cis-palmitoleate antagonizes saturated fat-induced proinflammatory macrophage polarization through an AMPK-dependent mechanism. Conclusion: Palmitoleate is a lipid mediator that confers an anti-inflammatory macrophage phenotype. Significance: Understanding lipid-mediated macrophage polarization is critical to develop nutritional or cell-based strategies to combat insulin resistance.

Original language	English
Pages (from-to)	16979-16988
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	290
Issue number	27
DOIs	https://doi.org/10.1074/jbc.M115.646992
State	Published - 3 Jul 2015
Externally published	Yes

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title = "Palmitoleate reverses high fat-induced proinflammatory macrophage polarization via AMP-activated protein kinase (AMPK)",

abstract = "Background: Elevated saturated fats during obesity activate proinflammatory pathways in macrophages, contributing to insulin resistance. Results: The monounsaturated fatty acid cis-palmitoleate antagonizes saturated fat-induced proinflammatory macrophage polarization through an AMPK-dependent mechanism. Conclusion: Palmitoleate is a lipid mediator that confers an anti-inflammatory macrophage phenotype. Significance: Understanding lipid-mediated macrophage polarization is critical to develop nutritional or cell-based strategies to combat insulin resistance.",

author = "Chan, \{Kenny L.\} and Pillon, \{Nicolas J.\} and Sivaloganathan, \{Darshan M.\} and Costford, \{Sheila R.\} and Zhi Liu and Marine Th{\'e}ret and Benedicte Chazaud and Amira Klip",

note = "Publisher Copyright: {\textcopyright} 2015 by The American Society for Biochemistry and Molecular Biology, Inc.",

year = "2015",

month = jul,

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doi = "10.1074/jbc.M115.646992",

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T1 - Palmitoleate reverses high fat-induced proinflammatory macrophage polarization via AMP-activated protein kinase (AMPK)

AU - Chan, Kenny L.

AU - Pillon, Nicolas J.

AU - Sivaloganathan, Darshan M.

AU - Costford, Sheila R.

AU - Liu, Zhi

AU - Théret, Marine

AU - Chazaud, Benedicte

AU - Klip, Amira

PY - 2015/7/3

Y1 - 2015/7/3

N2 - Background: Elevated saturated fats during obesity activate proinflammatory pathways in macrophages, contributing to insulin resistance. Results: The monounsaturated fatty acid cis-palmitoleate antagonizes saturated fat-induced proinflammatory macrophage polarization through an AMPK-dependent mechanism. Conclusion: Palmitoleate is a lipid mediator that confers an anti-inflammatory macrophage phenotype. Significance: Understanding lipid-mediated macrophage polarization is critical to develop nutritional or cell-based strategies to combat insulin resistance.

AB - Background: Elevated saturated fats during obesity activate proinflammatory pathways in macrophages, contributing to insulin resistance. Results: The monounsaturated fatty acid cis-palmitoleate antagonizes saturated fat-induced proinflammatory macrophage polarization through an AMPK-dependent mechanism. Conclusion: Palmitoleate is a lipid mediator that confers an anti-inflammatory macrophage phenotype. Significance: Understanding lipid-mediated macrophage polarization is critical to develop nutritional or cell-based strategies to combat insulin resistance.

UR - https://www.scopus.com/pages/publications/84936817998

U2 - 10.1074/jbc.M115.646992

DO - 10.1074/jbc.M115.646992

M3 - Article

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AN - SCOPUS:84936817998

SN - 0021-9258

VL - 290

SP - 16979

EP - 16988

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 27

ER -

Palmitoleate reverses high fat-induced proinflammatory macrophage polarization via AMP-activated protein kinase (AMPK)

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