Pallidal stimulation for cervical dystonia does not correct abnormal temporal discrimination

Anna Sadnicka; Okka Kimmich; Claudia Pisarek; Diane Ruge; Joe Galea; Panagiotis Kassavetis; Isabel Pareés; Tabish Saifee; Anna Molloy; David Bradley; Sean O'Riordan; Ludvic Zrinzo; Marwan Hariz; Kailash P. Bhatia; Patricia Limousin; Thomas Foltynie; John C. Rothwell; Michael Hutchinson; Mark J. Edwards

doi:10.1002/mds.25581

Pallidal stimulation for cervical dystonia does not correct abnormal temporal discrimination

Anna Sadnicka, Okka Kimmich, Claudia Pisarek, Diane Ruge, Joe Galea, Panagiotis Kassavetis, Isabel Pareés, Tabish Saifee, Anna Molloy, David Bradley, Sean O'Riordan, Ludvic Zrinzo, Marwan Hariz, Kailash P. Bhatia, Patricia Limousin, Thomas Foltynie, John C. Rothwell, Michael Hutchinson, Mark J. Edwards

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31 Scopus citations

Abstract

Background: We investigated whether clinical improvement observed after deep brain stimulation (DBS) of the globus pallidus internus (GPi) in cervical dystonia (CD) is paralleled by the normalisation of temporal discrimination thresholds (TDTs), a marker of abnormal sensory processing in CD. Methods: TDT was tested in 11 patients with CD after they received DBS and was compared with TDT scores from 24 patients with CD and a group of 61 controls. Results: A clear clinical response to GPi-DBS was demonstrated (total Toronto Western Spasmodic Torticollis Rating Scale scores fell from 50 to 18; P<0.001). In contrast, TDT remained abnormal in the CD-DBS group (P<0.001) and was not significantly different from the abnormal TDT range observed in CD. Conclusions: Underlying sensory abnormalities in temporal discrimination observed in dystonia do not seem to be corrected by successful GPi-DBS. This adds further data to the ongoing debate regarding which pathophysiological abnormalities observed in dystonia are likely to be causal in the genesis of the disease rather than epiphenomena observed secondary to abnormal motor activity.

Original language	English
Pages (from-to)	1874-1877
Number of pages	4
Journal	Movement Disorders
Volume	28
Issue number	13
DOIs	https://doi.org/10.1002/mds.25581
State	Published - Nov 2013
Externally published	Yes

Keywords

Cervical dystonia
Deep brain stimulation
Temporal discrimination threshold

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10.1002/mds.25581

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Sadnicka, A., Kimmich, O., Pisarek, C., Ruge, D., Galea, J., Kassavetis, P., Pareés, I., Saifee, T., Molloy, A., Bradley, D., O'Riordan, S., Zrinzo, L., Hariz, M., Bhatia, K. P., Limousin, P., Foltynie, T., Rothwell, J. C., Hutchinson, M., & Edwards, M. J. (2013). Pallidal stimulation for cervical dystonia does not correct abnormal temporal discrimination. Movement Disorders, 28(13), 1874-1877. https://doi.org/10.1002/mds.25581

@article{d1b9686311ca4831ab3f597504d3e956,

title = "Pallidal stimulation for cervical dystonia does not correct abnormal temporal discrimination",

abstract = "Background: We investigated whether clinical improvement observed after deep brain stimulation (DBS) of the globus pallidus internus (GPi) in cervical dystonia (CD) is paralleled by the normalisation of temporal discrimination thresholds (TDTs), a marker of abnormal sensory processing in CD. Methods: TDT was tested in 11 patients with CD after they received DBS and was compared with TDT scores from 24 patients with CD and a group of 61 controls. Results: A clear clinical response to GPi-DBS was demonstrated (total Toronto Western Spasmodic Torticollis Rating Scale scores fell from 50 to 18; P<0.001). In contrast, TDT remained abnormal in the CD-DBS group (P<0.001) and was not significantly different from the abnormal TDT range observed in CD. Conclusions: Underlying sensory abnormalities in temporal discrimination observed in dystonia do not seem to be corrected by successful GPi-DBS. This adds further data to the ongoing debate regarding which pathophysiological abnormalities observed in dystonia are likely to be causal in the genesis of the disease rather than epiphenomena observed secondary to abnormal motor activity.",

keywords = "Cervical dystonia, Deep brain stimulation, Temporal discrimination threshold",

author = "Anna Sadnicka and Okka Kimmich and Claudia Pisarek and Diane Ruge and Joe Galea and Panagiotis Kassavetis and Isabel Pare{\'e}s and Tabish Saifee and Anna Molloy and David Bradley and Sean O'Riordan and Ludvic Zrinzo and Marwan Hariz and Bhatia, {Kailash P.} and Patricia Limousin and Thomas Foltynie and Rothwell, {John C.} and Michael Hutchinson and Edwards, {Mark J.}",

year = "2013",

month = nov,

doi = "10.1002/mds.25581",

language = "English",

volume = "28",

pages = "1874--1877",

journal = "Movement Disorders",

issn = "0885-3185",

publisher = "John Wiley & Sons Inc.",

number = "13",

}

Sadnicka, A, Kimmich, O, Pisarek, C, Ruge, D, Galea, J, Kassavetis, P, Pareés, I, Saifee, T, Molloy, A, Bradley, D, O'Riordan, S, Zrinzo, L, Hariz, M, Bhatia, KP, Limousin, P, Foltynie, T, Rothwell, JC, Hutchinson, M & Edwards, MJ 2013, 'Pallidal stimulation for cervical dystonia does not correct abnormal temporal discrimination', Movement Disorders, vol. 28, no. 13, pp. 1874-1877. https://doi.org/10.1002/mds.25581

TY - JOUR

T1 - Pallidal stimulation for cervical dystonia does not correct abnormal temporal discrimination

AU - Sadnicka, Anna

AU - Kimmich, Okka

AU - Pisarek, Claudia

AU - Ruge, Diane

AU - Galea, Joe

AU - Kassavetis, Panagiotis

AU - Pareés, Isabel

AU - Saifee, Tabish

AU - Molloy, Anna

AU - Bradley, David

AU - O'Riordan, Sean

AU - Zrinzo, Ludvic

AU - Hariz, Marwan

AU - Bhatia, Kailash P.

AU - Limousin, Patricia

AU - Foltynie, Thomas

AU - Rothwell, John C.

AU - Hutchinson, Michael

AU - Edwards, Mark J.

PY - 2013/11

Y1 - 2013/11

N2 - Background: We investigated whether clinical improvement observed after deep brain stimulation (DBS) of the globus pallidus internus (GPi) in cervical dystonia (CD) is paralleled by the normalisation of temporal discrimination thresholds (TDTs), a marker of abnormal sensory processing in CD. Methods: TDT was tested in 11 patients with CD after they received DBS and was compared with TDT scores from 24 patients with CD and a group of 61 controls. Results: A clear clinical response to GPi-DBS was demonstrated (total Toronto Western Spasmodic Torticollis Rating Scale scores fell from 50 to 18; P<0.001). In contrast, TDT remained abnormal in the CD-DBS group (P<0.001) and was not significantly different from the abnormal TDT range observed in CD. Conclusions: Underlying sensory abnormalities in temporal discrimination observed in dystonia do not seem to be corrected by successful GPi-DBS. This adds further data to the ongoing debate regarding which pathophysiological abnormalities observed in dystonia are likely to be causal in the genesis of the disease rather than epiphenomena observed secondary to abnormal motor activity.

AB - Background: We investigated whether clinical improvement observed after deep brain stimulation (DBS) of the globus pallidus internus (GPi) in cervical dystonia (CD) is paralleled by the normalisation of temporal discrimination thresholds (TDTs), a marker of abnormal sensory processing in CD. Methods: TDT was tested in 11 patients with CD after they received DBS and was compared with TDT scores from 24 patients with CD and a group of 61 controls. Results: A clear clinical response to GPi-DBS was demonstrated (total Toronto Western Spasmodic Torticollis Rating Scale scores fell from 50 to 18; P<0.001). In contrast, TDT remained abnormal in the CD-DBS group (P<0.001) and was not significantly different from the abnormal TDT range observed in CD. Conclusions: Underlying sensory abnormalities in temporal discrimination observed in dystonia do not seem to be corrected by successful GPi-DBS. This adds further data to the ongoing debate regarding which pathophysiological abnormalities observed in dystonia are likely to be causal in the genesis of the disease rather than epiphenomena observed secondary to abnormal motor activity.

KW - Cervical dystonia

KW - Deep brain stimulation

KW - Temporal discrimination threshold

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U2 - 10.1002/mds.25581

DO - 10.1002/mds.25581

M3 - Article

C2 - 23853089

AN - SCOPUS:84887624243

SN - 0885-3185

VL - 28

SP - 1874

EP - 1877

JO - Movement Disorders

JF - Movement Disorders

IS - 13

ER -

Pallidal stimulation for cervical dystonia does not correct abnormal temporal discrimination

Abstract

Keywords

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