TY - JOUR
T1 - Pain pharmacology in migraine
T2 - Focus on CGRP and CGRP receptors
AU - Benemei, S.
AU - Nicoletti, P.
AU - Capone, J. A.
AU - Geppetti, Pierangelo
PY - 2007/5
Y1 - 2007/5
N2 - Over the last 100 years, the discovery of new analgesics has been a complex and difficult task. However, remarkable progress in the identification of novel molecular targets relevant for pain medicines has been reported. Here we will focus on the neuropeptide calcitonin generelated peptide (CGRP) and its receptors (CGRP-R) because of their role in migraine mechanism and migraine therapy. Recent preclinical and clinical data on the localisation, regulation and plasma levels of CGRP and on the function of CGRP-R will be summarised. The reviewed findings highlight the major function of CGRP in migraine and the use of CGRP-R antagonists as a novel approach for the treatment of migraine attack and, perhaps, as migraine prophylactic medicines.
AB - Over the last 100 years, the discovery of new analgesics has been a complex and difficult task. However, remarkable progress in the identification of novel molecular targets relevant for pain medicines has been reported. Here we will focus on the neuropeptide calcitonin generelated peptide (CGRP) and its receptors (CGRP-R) because of their role in migraine mechanism and migraine therapy. Recent preclinical and clinical data on the localisation, regulation and plasma levels of CGRP and on the function of CGRP-R will be summarised. The reviewed findings highlight the major function of CGRP in migraine and the use of CGRP-R antagonists as a novel approach for the treatment of migraine attack and, perhaps, as migraine prophylactic medicines.
KW - Calcitonin gene-related peptide
KW - Meninges
KW - Migraine
KW - Neurogenic vasodilatation
KW - Receptor antagonist
UR - http://www.scopus.com/inward/record.url?scp=34249306912&partnerID=8YFLogxK
U2 - 10.1007/s10072-007-0757-5
DO - 10.1007/s10072-007-0757-5
M3 - Article
C2 - 17508187
AN - SCOPUS:34249306912
SN - 1590-1874
VL - 28
SP - S89-S93
JO - Neurological Sciences
JF - Neurological Sciences
IS - SUPPL. 2
ER -