Paediatric HIV infection: The potential for cure

Philip J. Goulder, Sharon R. Lewin, Ellen M. Leitman

Research output: Contribution to journalReview articlepeer-review

69 Scopus citations

Abstract

Recent anecdotal reports of HIV-infected children who received early antiretroviral therapy (ART) and showed sustained control of viral replication even after ART discontinuation have raised the question of whether there is greater intrinsic potential for HIV remission, or even eradication ('cure'), in paediatric infection than in adult infection. This Review describes the influence of early initiation of ART, of immune ontogeny and of maternal factors on the potential for HIV cure in children and discusses the unique immunotherapeutic opportunities and obstacles that paediatric infection may present.

Original languageEnglish
Pages (from-to)259-271
Number of pages13
JournalNature Reviews Immunology
Volume16
Issue number4
DOIs
StatePublished - 30 Mar 2016
Externally publishedYes

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