Paediatric and adult glioblastoma: Multiform (epi)genomic culprits emerge

Dominik Sturm, Sebastian Bender, David T.W. Jones, Peter Lichter, Jacques Grill, Oren Becher, Cynthia Hawkins, Jacek Majewski, Chris Jones, Joseph F. Costello, Antonio Iavarone, Kenneth Aldape, Cameron W. Brennan, Nada Jabado, Stefan M. Pfister

Research output: Contribution to journalReview articlepeer-review

407 Scopus citations


We have extended our understanding of the molecular biology that underlies adult glioblastoma over many years. By contrast, high-grade gliomas in children and adolescents have remained a relatively under-investigated disease. The latest large-scale genomic and epigenomic profiling studies have yielded an unprecedented abundance of novel data and provided deeper insights into gliomagenesis across all age groups, which has highlighted key distinctions but also some commonalities. As we are on the verge of dissecting glioblastomas into meaningful biological subgroups, this Review summarizes the hallmark genetic alterations that are associated with distinct epigenetic features and patient characteristics in both paediatric and adult disease, and examines the complex interplay between the glioblastoma genome and epigenome.

Original languageEnglish
Pages (from-to)92-107
Number of pages16
JournalNature Reviews Cancer
Issue number2
StatePublished - Feb 2014
Externally publishedYes


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