PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination

Ana Mendanha Falcão; Mandy Meijer; Antonella Scaglione; Puneet Rinwa; Eneritz Agirre; Jialiang Liang; Sara C. Larsen; Abeer Heskol; Rebecca Frawley; Michael Klingener; Manuel Varas-Godoy; Alexandre A.S.F. Raposo; Patrik Ernfors; Diogo S. Castro; Michael L. Nielsen; Patrizia Casaccia; Gonçalo Castelo-Branco

doi:10.1016/j.celrep.2019.03.108

PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination

Ana Mendanha Falcão
, Mandy Meijer
, Antonella Scaglione
, Puneet Rinwa
, Eneritz Agirre
, Jialiang Liang
, Sara C. Larsen
, Abeer Heskol
, Rebecca Frawley
, Michael Klingener
, Manuel Varas-Godoy
, Alexandre A.S.F. Raposo
, Patrik Ernfors
, Diogo S. Castro
, Michael L. Nielsen
, Patrizia Casaccia
, Gonçalo Castelo-Branco

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Abstract

Falcão et al. demonstrate that PAD2-mediated citrullination, the conversion of peptidylarginine into peptidylcitrulline, has two roles in oligodendrocyte cells. In the nucleus, PAD2 acts as a chromatin modifier contributing to efficient oligodendrocyte precursor cell differentiation, while in the cytoplasm PAD2 is required for proper oligodendrocyte myelination.

Original language	English
Pages (from-to)	1090-1102.e10
Journal	Cell Reports
Volume	27
Issue number	4
DOIs	https://doi.org/10.1016/j.celrep.2019.03.108
State	Published - 23 Apr 2019

Keywords

PAD2
Padi2
SILAC
chromatin accessibility
citrullination
deamination
multiple sclerosis
myelin
oligodendrocytes
proteomics

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10.1016/j.celrep.2019.03.108

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Falcão, A. M., Meijer, M., Scaglione, A., Rinwa, P., Agirre, E., Liang, J., Larsen, S. C., Heskol, A., Frawley, R., Klingener, M., Varas-Godoy, M., Raposo, A. A. S. F., Ernfors, P., Castro, D. S., Nielsen, M. L., Casaccia, P., & Castelo-Branco, G. (2019). PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination. Cell Reports, 27(4), 1090-1102.e10. https://doi.org/10.1016/j.celrep.2019.03.108

@article{c85c72c7126d442896b9c2040f26ad0c,

title = "PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination",

abstract = "Falc{\~a}o et al. demonstrate that PAD2-mediated citrullination, the conversion of peptidylarginine into peptidylcitrulline, has two roles in oligodendrocyte cells. In the nucleus, PAD2 acts as a chromatin modifier contributing to efficient oligodendrocyte precursor cell differentiation, while in the cytoplasm PAD2 is required for proper oligodendrocyte myelination.",

keywords = "PAD2, Padi2, SILAC, chromatin accessibility, citrullination, deamination, multiple sclerosis, myelin, oligodendrocytes, proteomics",

author = "Falc{\~a}o, \{Ana Mendanha\} and Mandy Meijer and Antonella Scaglione and Puneet Rinwa and Eneritz Agirre and Jialiang Liang and Larsen, \{Sara C.\} and Abeer Heskol and Rebecca Frawley and Michael Klingener and Manuel Varas-Godoy and Raposo, \{Alexandre A.S.F.\} and Patrik Ernfors and Castro, \{Diogo S.\} and Nielsen, \{Michael L.\} and Patrizia Casaccia and Gon{\c c}alo Castelo-Branco",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2019",

month = apr,

day = "23",

doi = "10.1016/j.celrep.2019.03.108",

language = "English",

volume = "27",

pages = "1090--1102.e10",

journal = "Cell Reports",

issn = "2639-1856",

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Falcão, AM, Meijer, M, Scaglione, A, Rinwa, P, Agirre, E, Liang, J, Larsen, SC, Heskol, A, Frawley, R, Klingener, M, Varas-Godoy, M, Raposo, AASF, Ernfors, P, Castro, DS, Nielsen, ML, Casaccia, P & Castelo-Branco, G 2019, 'PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination', Cell Reports, vol. 27, no. 4, pp. 1090-1102.e10. https://doi.org/10.1016/j.celrep.2019.03.108

TY - JOUR

T1 - PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination

AU - Falcão, Ana Mendanha

AU - Meijer, Mandy

AU - Scaglione, Antonella

AU - Rinwa, Puneet

AU - Agirre, Eneritz

AU - Liang, Jialiang

AU - Larsen, Sara C.

AU - Heskol, Abeer

AU - Frawley, Rebecca

AU - Klingener, Michael

AU - Varas-Godoy, Manuel

AU - Raposo, Alexandre A.S.F.

AU - Ernfors, Patrik

AU - Castro, Diogo S.

AU - Nielsen, Michael L.

AU - Casaccia, Patrizia

AU - Castelo-Branco, Gonçalo

PY - 2019/4/23

Y1 - 2019/4/23

N2 - Falcão et al. demonstrate that PAD2-mediated citrullination, the conversion of peptidylarginine into peptidylcitrulline, has two roles in oligodendrocyte cells. In the nucleus, PAD2 acts as a chromatin modifier contributing to efficient oligodendrocyte precursor cell differentiation, while in the cytoplasm PAD2 is required for proper oligodendrocyte myelination.

AB - Falcão et al. demonstrate that PAD2-mediated citrullination, the conversion of peptidylarginine into peptidylcitrulline, has two roles in oligodendrocyte cells. In the nucleus, PAD2 acts as a chromatin modifier contributing to efficient oligodendrocyte precursor cell differentiation, while in the cytoplasm PAD2 is required for proper oligodendrocyte myelination.

KW - PAD2

KW - Padi2

KW - SILAC

KW - chromatin accessibility

KW - citrullination

KW - deamination

KW - multiple sclerosis

KW - myelin

KW - oligodendrocytes

KW - proteomics

UR - https://www.scopus.com/pages/publications/85064315917

U2 - 10.1016/j.celrep.2019.03.108

DO - 10.1016/j.celrep.2019.03.108

M3 - Article

C2 - 31018126

AN - SCOPUS:85064315917

SN - 2639-1856

VL - 27

SP - 1090-1102.e10

JO - Cell Reports

JF - Cell Reports

IS - 4

ER -

PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination

Abstract

Keywords

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