PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination

Ana Mendanha Falcão; Mandy Meijer; Antonella Scaglione; Puneet Rinwa; Eneritz Agirre; Jialiang Liang; Sara C. Larsen; Abeer Heskol; Rebecca Frawley; Michael Klingener; Manuel Varas-Godoy; Alexandre A.S.F. Raposo; Patrik Ernfors; Diogo S. Castro; Michael L. Nielsen; Patrizia Casaccia; Gonçalo Castelo-Branco

doi:10.1016/j.celrep.2019.03.108

PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination

Ana Mendanha Falcão, Mandy Meijer, Antonella Scaglione, Puneet Rinwa, Eneritz Agirre, Jialiang Liang, Sara C. Larsen, Abeer Heskol, Rebecca Frawley, Michael Klingener, Manuel Varas-Godoy, Alexandre A.S.F. Raposo, Patrik Ernfors, Diogo S. Castro, Michael L. Nielsen, Patrizia Casaccia, Gonçalo Castelo-Branco

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58 Scopus citations

Abstract

Falcão et al. demonstrate that PAD2-mediated citrullination, the conversion of peptidylarginine into peptidylcitrulline, has two roles in oligodendrocyte cells. In the nucleus, PAD2 acts as a chromatin modifier contributing to efficient oligodendrocyte precursor cell differentiation, while in the cytoplasm PAD2 is required for proper oligodendrocyte myelination.

Original language	English
Pages (from-to)	1090-1102.e10
Journal	Cell Reports
Volume	27
Issue number	4
DOIs	https://doi.org/10.1016/j.celrep.2019.03.108
State	Published - 23 Apr 2019

Keywords

PAD2
Padi2
SILAC
chromatin accessibility
citrullination
deamination
multiple sclerosis
myelin
oligodendrocytes
proteomics

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10.1016/j.celrep.2019.03.108

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Falcão, A. M., Meijer, M., Scaglione, A., Rinwa, P., Agirre, E., Liang, J., Larsen, S. C., Heskol, A., Frawley, R., Klingener, M., Varas-Godoy, M., Raposo, A. A. S. F., Ernfors, P., Castro, D. S., Nielsen, M. L., Casaccia, P., & Castelo-Branco, G. (2019). PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination. Cell Reports, 27(4), 1090-1102.e10. https://doi.org/10.1016/j.celrep.2019.03.108

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title = "PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination",

abstract = "Falc{\~a}o et al. demonstrate that PAD2-mediated citrullination, the conversion of peptidylarginine into peptidylcitrulline, has two roles in oligodendrocyte cells. In the nucleus, PAD2 acts as a chromatin modifier contributing to efficient oligodendrocyte precursor cell differentiation, while in the cytoplasm PAD2 is required for proper oligodendrocyte myelination.",

keywords = "PAD2, Padi2, SILAC, chromatin accessibility, citrullination, deamination, multiple sclerosis, myelin, oligodendrocytes, proteomics",

author = "Falc{\~a}o, {Ana Mendanha} and Mandy Meijer and Antonella Scaglione and Puneet Rinwa and Eneritz Agirre and Jialiang Liang and Larsen, {Sara C.} and Abeer Heskol and Rebecca Frawley and Michael Klingener and Manuel Varas-Godoy and Raposo, {Alexandre A.S.F.} and Patrik Ernfors and Castro, {Diogo S.} and Nielsen, {Michael L.} and Patrizia Casaccia and Gon{\c c}alo Castelo-Branco",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2019",

month = apr,

day = "23",

doi = "10.1016/j.celrep.2019.03.108",

language = "English",

volume = "27",

pages = "1090--1102.e10",

journal = "Cell Reports",

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Falcão, AM, Meijer, M, Scaglione, A, Rinwa, P, Agirre, E, Liang, J, Larsen, SC, Heskol, A, Frawley, R, Klingener, M, Varas-Godoy, M, Raposo, AASF, Ernfors, P, Castro, DS, Nielsen, ML, Casaccia, P & Castelo-Branco, G 2019, 'PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination', Cell Reports, vol. 27, no. 4, pp. 1090-1102.e10. https://doi.org/10.1016/j.celrep.2019.03.108

TY - JOUR

T1 - PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination

AU - Falcão, Ana Mendanha

AU - Meijer, Mandy

AU - Scaglione, Antonella

AU - Rinwa, Puneet

AU - Agirre, Eneritz

AU - Liang, Jialiang

AU - Larsen, Sara C.

AU - Heskol, Abeer

AU - Frawley, Rebecca

AU - Klingener, Michael

AU - Varas-Godoy, Manuel

AU - Raposo, Alexandre A.S.F.

AU - Ernfors, Patrik

AU - Castro, Diogo S.

AU - Nielsen, Michael L.

AU - Casaccia, Patrizia

AU - Castelo-Branco, Gonçalo

PY - 2019/4/23

Y1 - 2019/4/23

N2 - Falcão et al. demonstrate that PAD2-mediated citrullination, the conversion of peptidylarginine into peptidylcitrulline, has two roles in oligodendrocyte cells. In the nucleus, PAD2 acts as a chromatin modifier contributing to efficient oligodendrocyte precursor cell differentiation, while in the cytoplasm PAD2 is required for proper oligodendrocyte myelination.

AB - Falcão et al. demonstrate that PAD2-mediated citrullination, the conversion of peptidylarginine into peptidylcitrulline, has two roles in oligodendrocyte cells. In the nucleus, PAD2 acts as a chromatin modifier contributing to efficient oligodendrocyte precursor cell differentiation, while in the cytoplasm PAD2 is required for proper oligodendrocyte myelination.

KW - PAD2

KW - Padi2

KW - SILAC

KW - chromatin accessibility

KW - citrullination

KW - deamination

KW - multiple sclerosis

KW - myelin

KW - oligodendrocytes

KW - proteomics

UR - http://www.scopus.com/inward/record.url?scp=85064315917&partnerID=8YFLogxK

U2 - 10.1016/j.celrep.2019.03.108

DO - 10.1016/j.celrep.2019.03.108

M3 - Article

C2 - 31018126

AN - SCOPUS:85064315917

SN - 2211-1247

VL - 27

SP - 1090-1102.e10

JO - Cell Reports

JF - Cell Reports

IS - 4

ER -

PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination

Abstract

Keywords

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