@article{5dbc244fcbd742b581e2d7682b6a7039,
title = "Paclitaxel/ifosfamide or navelbine/ifosfamide chemotherapy for advanced non-small cell lung cancer: CALGB 9532",
abstract = "In order to explore non-cisplatin containing regimens for advanced non- small cell lung cancer, Cancer and Leukemia Group B conducted a randomized Phase-II study of two novel combinations, paclitaxel/ifosfamide and vinorelbine/ifosfamide. Both regimens were active with a 38\% response rate (95\% CI: 24\%, 53\%) and 31\% (95\% CI: 18\%, 47\%), respectively. Median survivals were 8.5 and 7.4 months. Toxicity, mostly neutropenia, was acceptable. These two combinations establish a 'proof of principle' that non-cisplatin containing regimens also have activity in this setting. (C) 2000 Elsevier Science Ireland Ltd.",
keywords = "Non-cisplatin containing regimens, Non-small cell lung cancer, Paclitaxel/ifosfamide, Vinorelbine/ifosfamide",
author = "Perry, \{Michael C.\} and Ihde, \{Daniel C.\} and Herndon, \{James E.\} and Grossbard, \{Michael L.\} and Grethein, \{Sara J.\} and Atkins, \{James N.\} and Vokes, \{Everett E.\} and Green, \{Mark R.\}",
note = "Funding Information: University of Missouri/Ellis Fischel Cancer Center, Columbia, MO — Michael C. Perry, MD, supported by CA12046; Funding Information: University of Alabama Birmingham, Birmingham, AL — Robert Diasio, MD, supported by CA47545; Funding Information: Southern Nevada Cancer Research Foundation CCOP, Las Vegas, NV — John Ellerton, MD, supported by CA35421; Funding Information: The research for CALGB 9532 was supported, in part, by grants from the National Cancer Institute (CA31946) to the Cancer and Leukemia Group B (Richard L. Schilsky, MD, Chairman). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the National Cancer Institute. Funding Information: University of Tennessee Memphis, Memphis, TN — Harvey B. Niell, MD, supported by CA47555; Funding Information: Dartmouth Medical School-Norris Cotton Cancer Center, Lebanon, NH — L. Herbert Maurer, MD, supported by CA04326; Funding Information: Southeast Cancer Control Consortium CCOP, Goldsboro, NC — James N. Atkins, MD, supported by CA45808; Funding Information: University of Iowa Hospitals, Iowa City, IA — Gerald H. Clamon, MD, supported by CA47642; ",
year = "2000",
month = apr,
doi = "10.1016/S0169-5002(99)00129-4",
language = "English",
volume = "28",
pages = "63--68",
journal = "Lung Cancer",
issn = "0169-5002",
publisher = "Elsevier Ireland Ltd",
number = "1",
}