p53 and Metabolism: Inside the TIGAR

Douglas R. Green; Jerry E. Chipuk

doi:10.1016/j.cell.2006.06.032

p53 and Metabolism: Inside the TIGAR

Douglas R. Green, Jerry E. Chipuk

Research output: Contribution to journal › Short survey › peer-review

214 Scopus citations

Abstract

The p53 tumor suppressor pathway coordinates DNA repair, cell-cycle arrest, apoptosis, and senescence to preserve genomic stability and prevent tumor formation. The discovery of three new target genes for p53 reveals unexpected functions for this tumor suppressor in the regulation of glucose metabolism and autophagy.

Original language	English
Pages (from-to)	30-32
Number of pages	3
Journal	Cell
Volume	126
Issue number	1
DOIs	https://doi.org/10.1016/j.cell.2006.06.032
State	Published - 14 Jul 2006
Externally published	Yes

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title = "p53 and Metabolism: Inside the TIGAR",

abstract = "The p53 tumor suppressor pathway coordinates DNA repair, cell-cycle arrest, apoptosis, and senescence to preserve genomic stability and prevent tumor formation. The discovery of three new target genes for p53 reveals unexpected functions for this tumor suppressor in the regulation of glucose metabolism and autophagy.",

author = "Green, {Douglas R.} and Chipuk, {Jerry E.}",

year = "2006",

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AU - Green, Douglas R.

AU - Chipuk, Jerry E.

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N2 - The p53 tumor suppressor pathway coordinates DNA repair, cell-cycle arrest, apoptosis, and senescence to preserve genomic stability and prevent tumor formation. The discovery of three new target genes for p53 reveals unexpected functions for this tumor suppressor in the regulation of glucose metabolism and autophagy.

AB - The p53 tumor suppressor pathway coordinates DNA repair, cell-cycle arrest, apoptosis, and senescence to preserve genomic stability and prevent tumor formation. The discovery of three new target genes for p53 reveals unexpected functions for this tumor suppressor in the regulation of glucose metabolism and autophagy.

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DO - 10.1016/j.cell.2006.06.032

M3 - Short survey

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AN - SCOPUS:33745713432

SN - 0092-8674

VL - 126

SP - 30

EP - 32

JO - Cell

JF - Cell

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ER -

p53 and Metabolism: Inside the TIGAR

Abstract

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