p53 and Development: Shedding Light on an Evolutionary Enigma

James J. Manfredi

doi:10.1016/j.devcel.2019.07.004

p53 and Development: Shedding Light on an Evolutionary Enigma

James J. Manfredi

Research output: Contribution to journal › Short survey › peer-review

2 Scopus citations

Abstract

In this issue of Developmental Cell, Bowen et al. (2019) show that targeting p53 hyperactivity to distinct compartments in vivo results in diverse and cell-type-specific phenotypes. These findings validate a role for p53 in certain human developmental syndromes and provide potential insight into its evolutionary conservation.

Original language	English
Pages (from-to)	128-129
Number of pages	2
Journal	Developmental Cell
Volume	50
Issue number	2
DOIs	https://doi.org/10.1016/j.devcel.2019.07.004
State	Published - 22 Jul 2019

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title = "p53 and Development: Shedding Light on an Evolutionary Enigma",

abstract = "In this issue of Developmental Cell, Bowen et al. (2019) show that targeting p53 hyperactivity to distinct compartments in vivo results in diverse and cell-type-specific phenotypes. These findings validate a role for p53 in certain human developmental syndromes and provide potential insight into its evolutionary conservation.",

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AB - In this issue of Developmental Cell, Bowen et al. (2019) show that targeting p53 hyperactivity to distinct compartments in vivo results in diverse and cell-type-specific phenotypes. These findings validate a role for p53 in certain human developmental syndromes and provide potential insight into its evolutionary conservation.

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U2 - 10.1016/j.devcel.2019.07.004

DO - 10.1016/j.devcel.2019.07.004

M3 - Short survey

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VL - 50

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JO - Developmental Cell

JF - Developmental Cell

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p53 and Development: Shedding Light on an Evolutionary Enigma

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