p38γ and p38δ mitogen activated protein kinases (MAPKs), new stars in the MAPK galaxy

Alejandra Escós; Ana Risco; Dayanira Alsina-Beauchamp; Ana Cuenda

doi:10.3389/fcell.2016.00031

p38γ and p38δ mitogen activated protein kinases (MAPKs), new stars in the MAPK galaxy

Alejandra Escós, Ana Risco, Dayanira Alsina-Beauchamp, Ana Cuenda

Research output: Contribution to journal › Short survey › peer-review

61 Scopus citations

Abstract

The protein kinases p38γ and p38δ belong to the p38 mitogen-activated protein kinase (MAPK) family. p38MAPK signaling controls many cellular processes and is one of the most conserved mechanisms in eukaryotes for the cellular response to environmental stress and inflammation. Although p38γ and p38δ are widely expressed, it is likely that they perform specific functions in different tissues. Their involvement in human pathologies such as inflammation-related diseases or cancer is starting to be uncovered. In this article we give a general overview and highlight recent advances made in defining the functions of p38γ and p38δ, focusing in innate immunity and inflammation. We consider the potential of the pharmacological targeting of MAPK pathways to treat autoimmune and inflammatory diseases and cancer.

Original language	English
Article number	31
Journal	Frontiers in Cell and Developmental Biology
Volume	4
Issue number	APR
DOIs	https://doi.org/10.3389/fcell.2016.00031
State	Published - 14 Apr 2016
Externally published	Yes

Keywords

Inflammation
Innate response
P38δ
p38γ

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title = "p38γ and p38δ mitogen activated protein kinases (MAPKs), new stars in the MAPK galaxy",

abstract = "The protein kinases p38γ and p38δ belong to the p38 mitogen-activated protein kinase (MAPK) family. p38MAPK signaling controls many cellular processes and is one of the most conserved mechanisms in eukaryotes for the cellular response to environmental stress and inflammation. Although p38γ and p38δ are widely expressed, it is likely that they perform specific functions in different tissues. Their involvement in human pathologies such as inflammation-related diseases or cancer is starting to be uncovered. In this article we give a general overview and highlight recent advances made in defining the functions of p38γ and p38δ, focusing in innate immunity and inflammation. We consider the potential of the pharmacological targeting of MAPK pathways to treat autoimmune and inflammatory diseases and cancer.",

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AU - Escós, Alejandra

AU - Risco, Ana

AU - Alsina-Beauchamp, Dayanira

AU - Cuenda, Ana

PY - 2016/4/14

Y1 - 2016/4/14

N2 - The protein kinases p38γ and p38δ belong to the p38 mitogen-activated protein kinase (MAPK) family. p38MAPK signaling controls many cellular processes and is one of the most conserved mechanisms in eukaryotes for the cellular response to environmental stress and inflammation. Although p38γ and p38δ are widely expressed, it is likely that they perform specific functions in different tissues. Their involvement in human pathologies such as inflammation-related diseases or cancer is starting to be uncovered. In this article we give a general overview and highlight recent advances made in defining the functions of p38γ and p38δ, focusing in innate immunity and inflammation. We consider the potential of the pharmacological targeting of MAPK pathways to treat autoimmune and inflammatory diseases and cancer.

AB - The protein kinases p38γ and p38δ belong to the p38 mitogen-activated protein kinase (MAPK) family. p38MAPK signaling controls many cellular processes and is one of the most conserved mechanisms in eukaryotes for the cellular response to environmental stress and inflammation. Although p38γ and p38δ are widely expressed, it is likely that they perform specific functions in different tissues. Their involvement in human pathologies such as inflammation-related diseases or cancer is starting to be uncovered. In this article we give a general overview and highlight recent advances made in defining the functions of p38γ and p38δ, focusing in innate immunity and inflammation. We consider the potential of the pharmacological targeting of MAPK pathways to treat autoimmune and inflammatory diseases and cancer.

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p38γ and p38δ mitogen activated protein kinases (MAPKs), new stars in the MAPK galaxy

Abstract

Keywords

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