TY - JOUR
T1 - p27Kip1 and stathmin share the stage for the first time
AU - Iancu-Rubin, Camelia
AU - Atweh, George F.
PY - 2005/7
Y1 - 2005/7
N2 - Cell migration is essential for development, morphogenesis, tissue repair and tumor metastasis. p27Kip1 and stathmin are two cell-cycle-regulatory proteins that were recently shown to play important roles in the regulation of cell migration. In this article, we discuss a new study that places p27Kip1 and stathmin in the same pathway by showing that stathmin, a microtubule-regulatory protein, mediates the effects of p27 Kip1 on cell motility. These findings provide new insights into migration and metastasis of tumor cells and the relationship of these processes to cell proliferation.
AB - Cell migration is essential for development, morphogenesis, tissue repair and tumor metastasis. p27Kip1 and stathmin are two cell-cycle-regulatory proteins that were recently shown to play important roles in the regulation of cell migration. In this article, we discuss a new study that places p27Kip1 and stathmin in the same pathway by showing that stathmin, a microtubule-regulatory protein, mediates the effects of p27 Kip1 on cell motility. These findings provide new insights into migration and metastasis of tumor cells and the relationship of these processes to cell proliferation.
UR - http://www.scopus.com/inward/record.url?scp=21744447838&partnerID=8YFLogxK
U2 - 10.1016/j.tcb.2005.05.008
DO - 10.1016/j.tcb.2005.05.008
M3 - Short survey
C2 - 15951178
AN - SCOPUS:21744447838
SN - 0962-8924
VL - 15
SP - 346
EP - 348
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 7
ER -