p27Kip1 and stathmin share the stage for the first time

Camelia Iancu-Rubin, George F. Atweh

Research output: Contribution to journalShort surveypeer-review

40 Scopus citations

Abstract

Cell migration is essential for development, morphogenesis, tissue repair and tumor metastasis. p27Kip1 and stathmin are two cell-cycle-regulatory proteins that were recently shown to play important roles in the regulation of cell migration. In this article, we discuss a new study that places p27Kip1 and stathmin in the same pathway by showing that stathmin, a microtubule-regulatory protein, mediates the effects of p27 Kip1 on cell motility. These findings provide new insights into migration and metastasis of tumor cells and the relationship of these processes to cell proliferation.

Original languageEnglish
Pages (from-to)346-348
Number of pages3
JournalTrends in Cell Biology
Volume15
Issue number7
DOIs
StatePublished - Jul 2005

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