Pénétration dans les structures coliques de la pipéracilline utilisée en prophylaxie dans la chirurgie colorectale

F. Jehl; M. O. Husson; D. Lescut; G. Arbon; P. Vincent; P. Quandale; J. F. Colombel

doi:10.1016/S0399-077X(05)81361-7

Pénétration dans les structures coliques de la pipéracilline utilisée en prophylaxie dans la chirurgie colorectale

Translated title of the contribution: Tissue penetration of piperacillin into the colonic structures

F. Jehl, M. O. Husson, D. Lescut, G. Arbon, P. Vincent, P. Quandale, J. F. Colombel

Research output: Contribution to journal › Article › peer-review

Abstract

The tissue penetration of intravenous piperacillin (4 g) into the colonic structures was investigated in 18 patients (7 men, 11 women, 61 ± 16 years old) undergoing colorectal surgery for a lieberkühnian adenocarcinoma. In the peri-colonic ganglions, mean piperacillin concentrations were 25.6 ± 21.5 and 18.0 ± 21.5 μg/g respectively 41.9 ± 13.7 and 91.1 ± 26.1 minutes after administration. In the colonic wall, concentrations were 26.9 ± 24.5 and 11.9 ± 12.6 μg/g respectively 91.1 ± 26.1 and 171.6 ± 26.7 minutes after administration. These concentrations are clearly above the MICs90 of piperacillin against pathogens targeted by the antibioprophylaxis in colorectal surgery, i.e. Enterobacteriaceae, Enterococcus spp and Bacteroides fragilis.

Translated title of the contribution	Tissue penetration of piperacillin into the colonic structures
Original language	French
Pages (from-to)	1206-1209
Number of pages	4
Journal	Medecine et Maladies Infectieuses
Volume	25
Issue number	12
DOIs	https://doi.org/10.1016/S0399-077X(05)81361-7
State	Published - Dec 1995
Externally published	Yes

Keywords

Antibiotic prophylaxis
Colorectal surgery
Piperacilline
Tissue penetration

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@article{47276edae6d04fb99bee9bcd5ef9fe4b,

title = "P{\'e}n{\'e}tration dans les structures coliques de la pip{\'e}racilline utilis{\'e}e en prophylaxie dans la chirurgie colorectale",

abstract = "The tissue penetration of intravenous piperacillin (4 g) into the colonic structures was investigated in 18 patients (7 men, 11 women, 61 ± 16 years old) undergoing colorectal surgery for a lieberk{\"u}hnian adenocarcinoma. In the peri-colonic ganglions, mean piperacillin concentrations were 25.6 ± 21.5 and 18.0 ± 21.5 μg/g respectively 41.9 ± 13.7 and 91.1 ± 26.1 minutes after administration. In the colonic wall, concentrations were 26.9 ± 24.5 and 11.9 ± 12.6 μg/g respectively 91.1 ± 26.1 and 171.6 ± 26.7 minutes after administration. These concentrations are clearly above the MICs90 of piperacillin against pathogens targeted by the antibioprophylaxis in colorectal surgery, i.e. Enterobacteriaceae, Enterococcus spp and Bacteroides fragilis.",

keywords = "Antibiotic prophylaxis, Colorectal surgery, Piperacilline, Tissue penetration",

author = "F. Jehl and Husson, {M. O.} and D. Lescut and G. Arbon and P. Vincent and P. Quandale and Colombel, {J. F.}",

year = "1995",

month = dec,

doi = "10.1016/S0399-077X(05)81361-7",

language = "French",

volume = "25",

pages = "1206--1209",

journal = "Medecine et Maladies Infectieuses",

issn = "0399-077X",

publisher = "Elsevier Masson s.r.l.",

number = "12",

}

TY - JOUR

T1 - Pénétration dans les structures coliques de la pipéracilline utilisée en prophylaxie dans la chirurgie colorectale

AU - Jehl, F.

AU - Husson, M. O.

AU - Lescut, D.

AU - Arbon, G.

AU - Vincent, P.

AU - Quandale, P.

AU - Colombel, J. F.

PY - 1995/12

Y1 - 1995/12

N2 - The tissue penetration of intravenous piperacillin (4 g) into the colonic structures was investigated in 18 patients (7 men, 11 women, 61 ± 16 years old) undergoing colorectal surgery for a lieberkühnian adenocarcinoma. In the peri-colonic ganglions, mean piperacillin concentrations were 25.6 ± 21.5 and 18.0 ± 21.5 μg/g respectively 41.9 ± 13.7 and 91.1 ± 26.1 minutes after administration. In the colonic wall, concentrations were 26.9 ± 24.5 and 11.9 ± 12.6 μg/g respectively 91.1 ± 26.1 and 171.6 ± 26.7 minutes after administration. These concentrations are clearly above the MICs90 of piperacillin against pathogens targeted by the antibioprophylaxis in colorectal surgery, i.e. Enterobacteriaceae, Enterococcus spp and Bacteroides fragilis.

AB - The tissue penetration of intravenous piperacillin (4 g) into the colonic structures was investigated in 18 patients (7 men, 11 women, 61 ± 16 years old) undergoing colorectal surgery for a lieberkühnian adenocarcinoma. In the peri-colonic ganglions, mean piperacillin concentrations were 25.6 ± 21.5 and 18.0 ± 21.5 μg/g respectively 41.9 ± 13.7 and 91.1 ± 26.1 minutes after administration. In the colonic wall, concentrations were 26.9 ± 24.5 and 11.9 ± 12.6 μg/g respectively 91.1 ± 26.1 and 171.6 ± 26.7 minutes after administration. These concentrations are clearly above the MICs90 of piperacillin against pathogens targeted by the antibioprophylaxis in colorectal surgery, i.e. Enterobacteriaceae, Enterococcus spp and Bacteroides fragilis.

KW - Antibiotic prophylaxis

KW - Colorectal surgery

KW - Piperacilline

KW - Tissue penetration

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U2 - 10.1016/S0399-077X(05)81361-7

DO - 10.1016/S0399-077X(05)81361-7

M3 - Article

AN - SCOPUS:0029560994

SN - 0399-077X

VL - 25

SP - 1206

EP - 1209

JO - Medecine et Maladies Infectieuses

JF - Medecine et Maladies Infectieuses

IS - 12

ER -

Pénétration dans les structures coliques de la pipéracilline utilisée en prophylaxie dans la chirurgie colorectale

Abstract

Keywords

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