Pénétration dans les structures coliques de la pipéracilline utilisée en prophylaxie dans la chirurgie colorectale

Translated title of the contribution: Tissue penetration of piperacillin into the colonic structures

F. Jehl, M. O. Husson, D. Lescut, G. Arbon, P. Vincent, P. Quandale, J. F. Colombel

Research output: Contribution to journalArticlepeer-review


The tissue penetration of intravenous piperacillin (4 g) into the colonic structures was investigated in 18 patients (7 men, 11 women, 61 ± 16 years old) undergoing colorectal surgery for a lieberkühnian adenocarcinoma. In the peri-colonic ganglions, mean piperacillin concentrations were 25.6 ± 21.5 and 18.0 ± 21.5 μg/g respectively 41.9 ± 13.7 and 91.1 ± 26.1 minutes after administration. In the colonic wall, concentrations were 26.9 ± 24.5 and 11.9 ± 12.6 μg/g respectively 91.1 ± 26.1 and 171.6 ± 26.7 minutes after administration. These concentrations are clearly above the MICs90 of piperacillin against pathogens targeted by the antibioprophylaxis in colorectal surgery, i.e. Enterobacteriaceae, Enterococcus spp and Bacteroides fragilis.

Translated title of the contributionTissue penetration of piperacillin into the colonic structures
Original languageFrench
Pages (from-to)1206-1209
Number of pages4
JournalMedecine et Maladies Infectieuses
Issue number12
StatePublished - Dec 1995
Externally publishedYes


  • Antibiotic prophylaxis
  • Colorectal surgery
  • Piperacilline
  • Tissue penetration


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