Oxytocin administration, instillation to abortion time, and morbidity associated with saline instillation

G. S. Berger, D. A. Edelman, T. D. Kerenyi

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Among 4,069 healthy gravidas undergoing saline abortion, patients administered intravenous oxytocin had a significantly shorter instillation to abortion time (median, 25.5 hr) than did patients not administered oxytocin (median, 33.3 hr). The instillation to abortion time was independent of the rate of oxytocin administration, which ranged from 1 to 4 U. per hour (17 to 67 mU. per min), but was associated with the time at which oxytocin infusion was begun. When oxytocin infusion was started within 8 hr after instillation, a shortened time from instillation to abortion was observed. Although oxytocin augmentation may result in a lower proportion of patients being exposed to the risk of infection associated with prolonged intervals from instillation to abortion, this potential advantage appears counterbalanced by an increased incidence of clinical consumptive coagulopathy associated with instillation to abortion intervals of less than 24 hr.

Original languageEnglish
Pages (from-to)941-946
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Volume121
Issue number7
DOIs
StatePublished - 1975
Externally publishedYes

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