TY - JOUR
T1 - Oxytocin administration, instillation to abortion time, and morbidity associated with saline instillation
AU - Berger, G. S.
AU - Edelman, D. A.
AU - Kerenyi, T. D.
N1 - Funding Information:
Supported in part by the International Fertility Research Program (AID I csd 2979), Carolina Population Center.
PY - 1975
Y1 - 1975
N2 - Among 4,069 healthy gravidas undergoing saline abortion, patients administered intravenous oxytocin had a significantly shorter instillation to abortion time (median, 25.5 hr) than did patients not administered oxytocin (median, 33.3 hr). The instillation to abortion time was independent of the rate of oxytocin administration, which ranged from 1 to 4 U. per hour (17 to 67 mU. per min), but was associated with the time at which oxytocin infusion was begun. When oxytocin infusion was started within 8 hr after instillation, a shortened time from instillation to abortion was observed. Although oxytocin augmentation may result in a lower proportion of patients being exposed to the risk of infection associated with prolonged intervals from instillation to abortion, this potential advantage appears counterbalanced by an increased incidence of clinical consumptive coagulopathy associated with instillation to abortion intervals of less than 24 hr.
AB - Among 4,069 healthy gravidas undergoing saline abortion, patients administered intravenous oxytocin had a significantly shorter instillation to abortion time (median, 25.5 hr) than did patients not administered oxytocin (median, 33.3 hr). The instillation to abortion time was independent of the rate of oxytocin administration, which ranged from 1 to 4 U. per hour (17 to 67 mU. per min), but was associated with the time at which oxytocin infusion was begun. When oxytocin infusion was started within 8 hr after instillation, a shortened time from instillation to abortion was observed. Although oxytocin augmentation may result in a lower proportion of patients being exposed to the risk of infection associated with prolonged intervals from instillation to abortion, this potential advantage appears counterbalanced by an increased incidence of clinical consumptive coagulopathy associated with instillation to abortion intervals of less than 24 hr.
UR - http://www.scopus.com/inward/record.url?scp=0016691936&partnerID=8YFLogxK
U2 - 10.1016/0002-9378(75)90913-8
DO - 10.1016/0002-9378(75)90913-8
M3 - Article
C2 - 1115183
AN - SCOPUS:0016691936
SN - 0002-9378
VL - 121
SP - 941
EP - 946
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 7
ER -