Oxyhemoglobin concentrations do not support hemoglobinopathy in COVID-19

Patrick Maher, Hamna Zafar, Kusum Mathews

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Based on computerized modeling studies, it has been postulated that the severe hypoxemia in COVID-19 may result from impaired oxygen carrying capacity on hemoglobin. Standard pulse oximetry may not detect hypoxemia resulting from hemoglobinopathy, therefore hemoglobin co-oximetry is needed to evaluate this divergence. In a clinical data analysis of a multicenter cohort of hospitalized patients with COVID-19, we found a minimal effect, less than 1%, on the correlation between oxyhemoglobin concentration and predicted oxygen saturation in the presence of COVID-19 infection. This effect is unlikely to explain the clinically significant hypoxia in COVID-19 patients.

Original languageEnglish
Article number106597
JournalRespiratory Medicine
StatePublished - Oct 2021


  • COVID-19
  • Hemoglobinopathy
  • Hypoxia
  • Respiratory failure


Dive into the research topics of 'Oxyhemoglobin concentrations do not support hemoglobinopathy in COVID-19'. Together they form a unique fingerprint.

Cite this