Oxidative stress regulation of stem and progenitor cells

Shazib Pervaiz, Reshma Taneja, Saghi Ghaffari

Research output: Contribution to journalReview articlepeer-review

147 Scopus citations


In recent years, it has become clear that balanced regulation of reactive oxygen species is of critical significance for cell-fate determination as well as for stem cell development, function, and survival. Although many questions regarding intracellular redox status regulation of stem cell fate remain, we review here what is known regarding the impact of cell-fate signaling as shown with a variety of human cancer cells and more recently on cancer-initiating cells and on the regenerative capacity of skeletal muscle and hematopoietic tissue and their stem cells. We also discuss the role of altered intracellular redox status as a potential primary pathogenic mechanism in muscular dystrophy and hematopoietic pathologies. Studies discussed here illustrate how understanding altered redox regulation of stem cell behavior may contribute to the development of novel stem cell therapies. Antioxid. Redox Signal. 11, 2777-2789.

Original languageEnglish
Pages (from-to)2777-2789
Number of pages13
JournalAntioxidants and Redox Signaling
Issue number11
StatePublished - 1 Nov 2009


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