TY - JOUR
T1 - Oxidative stress and fetal weight
T2 - observational findings from a pregnancy cohort in New York City
AU - Duh-Leong, Carol
AU - Ghassabian, Akhgar
AU - Cowell, Whitney
AU - Shahin, Sarvenaz
AU - Liu, Mengling
AU - Kannan, Kurunthachalam
AU - Pierce, Kristyn A.
AU - Mehta-Lee, Shilpi S.
AU - Long, Sara E.
AU - Wang, Yuyan
AU - Yang, Wenqing
AU - Afanasyeva, Yelena
AU - Trasande, Leonardo
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer Nature America, Inc. 2025.
PY - 2025
Y1 - 2025
N2 - Objective: To examine associations between oxidative stress and fetal weight across pregnancy. Study design: Cohort study of pregnant participants from 2016-2021 in New York City with urinary lipid, protein, and DNA oxidative stress biomarkers (<18, 18–25, >25 weeks) and estimated fetal weight from ultrasound fetal biometry with the HadlockIII formula (20, 30, 36 weeks). Result: Among 1408 participants, oxidative stress biomarkers of lipid peroxidation and DNA damage were associated with smaller estimated fetal weight at 30 and 36 weeks (ranging from B = –3.9 grams/unit increase [95% CI: –6.9, –0.9; 8,15 − PGF2α] to –20.3 [95% CI: –27.9, –12.8; 8 − OHdG]), particularly among fetuses at the 25th percentile. Oxidative stress biomarkers of protein damage were associated with larger estimated fetal weight at 20 (3.4 [95% CI: 1.2, 5.7]) and 36 weeks (16.5 [95% CI: 5.2, 27.8]). Conclusion: These findings advance our understanding of different oxidative stress pathways and their potential role in fetal growth.
AB - Objective: To examine associations between oxidative stress and fetal weight across pregnancy. Study design: Cohort study of pregnant participants from 2016-2021 in New York City with urinary lipid, protein, and DNA oxidative stress biomarkers (<18, 18–25, >25 weeks) and estimated fetal weight from ultrasound fetal biometry with the HadlockIII formula (20, 30, 36 weeks). Result: Among 1408 participants, oxidative stress biomarkers of lipid peroxidation and DNA damage were associated with smaller estimated fetal weight at 30 and 36 weeks (ranging from B = –3.9 grams/unit increase [95% CI: –6.9, –0.9; 8,15 − PGF2α] to –20.3 [95% CI: –27.9, –12.8; 8 − OHdG]), particularly among fetuses at the 25th percentile. Oxidative stress biomarkers of protein damage were associated with larger estimated fetal weight at 20 (3.4 [95% CI: 1.2, 5.7]) and 36 weeks (16.5 [95% CI: 5.2, 27.8]). Conclusion: These findings advance our understanding of different oxidative stress pathways and their potential role in fetal growth.
UR - https://www.scopus.com/pages/publications/105021433446
U2 - 10.1038/s41372-025-02464-1
DO - 10.1038/s41372-025-02464-1
M3 - Article
AN - SCOPUS:105021433446
SN - 0743-8346
JO - Journal of Perinatology
JF - Journal of Perinatology
ER -