Abstract
Objective: The aim of the present case report is to describe a potential interaction between valproic acid and oxcarbazepine that resulted in hepatic injury. Methods: We report the case of a 46-year-old man with schizoaffective disorder who was cross-titrated from valproic acid to oxcarbazepine because of liver injury. Results: Initiation of oxcarbazepine four days after stopping valproic acid produced a significant elevation in liver enzymes that normalized with oxcarbazepine discontinuation and did not reappear with its reintroduction five days later. Conclusions: Our findings suggest that a longer washout period or another agent should be considered when transitioning from valproic acid to oxcarbazepine.
| Original language | English |
|---|---|
| Pages (from-to) | 307-309 |
| Number of pages | 3 |
| Journal | Bipolar Disorders |
| Volume | 18 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1 May 2016 |
| Externally published | Yes |
Keywords
- Liver injury
- Oxcarbazepine
- Transaminitis
- Valproic acid