Oxazolidinones as novel human CCR8 antagonists

Jian Jin; Yonghui Wang; Feng Wang; Jeffery K. Kerns; Victoria M. Vinader; Ashley P. Hancock; Matthew J. Lindon; Graeme I. Stevenson; Dwight M. Morrow; Parvathi Rao; Cuc Nguyen; Victoria J. Barrett; Chris Browning; Guido Hartmann; David P. Andrew; Henry M. Sarau; James J. Foley; Anthony J. Jurewicz; James A. Fornwald; Andy J. Harker; Michael L. Moore; Ralph A. Rivero; Kristen E. Belmonte; Helen E. Connor

doi:10.1016/j.bmcl.2006.12.076

Oxazolidinones as novel human CCR8 antagonists

Jian Jin, Yonghui Wang, Feng Wang, Jeffery K. Kerns, Victoria M. Vinader, Ashley P. Hancock, Matthew J. Lindon, Graeme I. Stevenson, Dwight M. Morrow, Parvathi Rao, Cuc Nguyen, Victoria J. Barrett, Chris Browning, Guido Hartmann, David P. Andrew, Henry M. Sarau, James J. Foley, Anthony J. Jurewicz, James A. Fornwald, Andy J. HarkerMichael L. Moore, Ralph A. Rivero, Kristen E. Belmonte, Helen E. Connor

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

High-throughput screening of the corporate compound collection led to the discovery of a novel series of N-substituted-5-aryl-oxazolidinones as potent human CCR8 antagonists. The synthesis, structure-activity relationships, and optimization of the series that led to the identification of SB-649701 (1a), are described.

Original language	English
Pages (from-to)	1722-1725
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	17
Issue number	6
DOIs	https://doi.org/10.1016/j.bmcl.2006.12.076
State	Published - 15 Mar 2007
Externally published	Yes

Keywords

Antagonists
Asthma
CCR8
Chemokine receptors
HIV
N-substituted-5-aryl-oxazolidinones

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10.1016/j.bmcl.2006.12.076

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Jin, J., Wang, Y., Wang, F., Kerns, J. K., Vinader, V. M., Hancock, A. P., Lindon, M. J., Stevenson, G. I., Morrow, D. M., Rao, P., Nguyen, C., Barrett, V. J., Browning, C., Hartmann, G., Andrew, D. P., Sarau, H. M., Foley, J. J., Jurewicz, A. J., Fornwald, J. A., ... Connor, H. E. (2007). Oxazolidinones as novel human CCR8 antagonists. Bioorganic and Medicinal Chemistry Letters, 17(6), 1722-1725. https://doi.org/10.1016/j.bmcl.2006.12.076

@article{23adbd12ff644069a538f4811db51912,

title = "Oxazolidinones as novel human CCR8 antagonists",

abstract = "High-throughput screening of the corporate compound collection led to the discovery of a novel series of N-substituted-5-aryl-oxazolidinones as potent human CCR8 antagonists. The synthesis, structure-activity relationships, and optimization of the series that led to the identification of SB-649701 (1a), are described.",

keywords = "Antagonists, Asthma, CCR8, Chemokine receptors, HIV, N-substituted-5-aryl-oxazolidinones",

author = "Jian Jin and Yonghui Wang and Feng Wang and Kerns, \{Jeffery K.\} and Vinader, \{Victoria M.\} and Hancock, \{Ashley P.\} and Lindon, \{Matthew J.\} and Stevenson, \{Graeme I.\} and Morrow, \{Dwight M.\} and Parvathi Rao and Cuc Nguyen and Barrett, \{Victoria J.\} and Chris Browning and Guido Hartmann and Andrew, \{David P.\} and Sarau, \{Henry M.\} and Foley, \{James J.\} and Jurewicz, \{Anthony J.\} and Fornwald, \{James A.\} and Harker, \{Andy J.\} and Moore, \{Michael L.\} and Rivero, \{Ralph A.\} and Belmonte, \{Kristen E.\} and Connor, \{Helen E.\}",

year = "2007",

month = mar,

day = "15",

doi = "10.1016/j.bmcl.2006.12.076",

language = "English",

volume = "17",

pages = "1722--1725",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd.",

number = "6",

}

Jin, J, Wang, Y, Wang, F, Kerns, JK, Vinader, VM, Hancock, AP, Lindon, MJ, Stevenson, GI, Morrow, DM, Rao, P, Nguyen, C, Barrett, VJ, Browning, C, Hartmann, G, Andrew, DP, Sarau, HM, Foley, JJ, Jurewicz, AJ, Fornwald, JA, Harker, AJ, Moore, ML, Rivero, RA, Belmonte, KE & Connor, HE 2007, 'Oxazolidinones as novel human CCR8 antagonists', Bioorganic and Medicinal Chemistry Letters, vol. 17, no. 6, pp. 1722-1725. https://doi.org/10.1016/j.bmcl.2006.12.076

TY - JOUR

T1 - Oxazolidinones as novel human CCR8 antagonists

AU - Jin, Jian

AU - Wang, Yonghui

AU - Wang, Feng

AU - Kerns, Jeffery K.

AU - Vinader, Victoria M.

AU - Hancock, Ashley P.

AU - Lindon, Matthew J.

AU - Stevenson, Graeme I.

AU - Morrow, Dwight M.

AU - Rao, Parvathi

AU - Nguyen, Cuc

AU - Barrett, Victoria J.

AU - Browning, Chris

AU - Hartmann, Guido

AU - Andrew, David P.

AU - Sarau, Henry M.

AU - Foley, James J.

AU - Jurewicz, Anthony J.

AU - Fornwald, James A.

AU - Harker, Andy J.

AU - Moore, Michael L.

AU - Rivero, Ralph A.

AU - Belmonte, Kristen E.

AU - Connor, Helen E.

PY - 2007/3/15

Y1 - 2007/3/15

N2 - High-throughput screening of the corporate compound collection led to the discovery of a novel series of N-substituted-5-aryl-oxazolidinones as potent human CCR8 antagonists. The synthesis, structure-activity relationships, and optimization of the series that led to the identification of SB-649701 (1a), are described.

AB - High-throughput screening of the corporate compound collection led to the discovery of a novel series of N-substituted-5-aryl-oxazolidinones as potent human CCR8 antagonists. The synthesis, structure-activity relationships, and optimization of the series that led to the identification of SB-649701 (1a), are described.

KW - Antagonists

KW - Asthma

KW - CCR8

KW - Chemokine receptors

KW - HIV

KW - N-substituted-5-aryl-oxazolidinones

UR - https://www.scopus.com/pages/publications/33847224885

U2 - 10.1016/j.bmcl.2006.12.076

DO - 10.1016/j.bmcl.2006.12.076

M3 - Article

C2 - 17267215

AN - SCOPUS:33847224885

SN - 0960-894X

VL - 17

SP - 1722

EP - 1725

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 6

ER -

Oxazolidinones as novel human CCR8 antagonists

Abstract

Keywords

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