Ovulation induction and polycystic ovary syndrome

The management of anovulatory infertility in women with polycystic ovary syndrome (PCOS) has evolved significantly over the last 60 years. PCOS is now known to be a heterogeneous collection of endocrine disturbances often involving hyperandrogenism and insulin resistance. Treatments have become more sophisticated and should target specific endocrinopathies. A comprehensive approach toward inducing ovulation in these patients must take into consideration the complexities of the disease and the risks and benefits of a range of approaches. In this article, a historical perspective of the disease is presented and a variety of methodologies used to safely induce ovulation in patients with PCOS is discussed.