TY - JOUR
T1 - Overview of Prostate Anatomy, Histology, and Pathology
AU - Lee, Christine H.
AU - Akin-Olugbade, Oluyemi
AU - Kirschenbaum, Alexander
PY - 2011/9
Y1 - 2011/9
N2 - The human prostate is heterogeneous with regard to its embryologic origin. The two most prevalent diseases of aging males, benign prostatic hyperplasia and prostate cancer (PCa), arise from different zones within the prostate. The biology of PCa is also heterogeneous and even within a single individual there often exist prostate cancers with varying potential to progress and metastasize. Through careful study of the histology and molecular signatures of both the human and mouse-modeled disease, treatment decisions can be tailored to individual cases so as to optimize efficacy and minimize side effects from therapy.
AB - The human prostate is heterogeneous with regard to its embryologic origin. The two most prevalent diseases of aging males, benign prostatic hyperplasia and prostate cancer (PCa), arise from different zones within the prostate. The biology of PCa is also heterogeneous and even within a single individual there often exist prostate cancers with varying potential to progress and metastasize. Through careful study of the histology and molecular signatures of both the human and mouse-modeled disease, treatment decisions can be tailored to individual cases so as to optimize efficacy and minimize side effects from therapy.
KW - Adenocarcinoma
KW - Androgen receptor
KW - Mouse model
KW - Prostate
KW - Prostatic intraepithelial neoplasia
UR - http://www.scopus.com/inward/record.url?scp=80052212356&partnerID=8YFLogxK
U2 - 10.1016/j.ecl.2011.05.012
DO - 10.1016/j.ecl.2011.05.012
M3 - Review article
C2 - 21889721
AN - SCOPUS:80052212356
SN - 0889-8529
VL - 40
SP - 565
EP - 575
JO - Endocrinology and Metabolism Clinics of North America
JF - Endocrinology and Metabolism Clinics of North America
IS - 3
ER -