Overview of Myeloproliferative Neoplasms: History, Pathogenesis, Diagnostic Criteria, and Complications

Douglas Tremblay, Abdulraheem Yacoub, Ronald Hoffman

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Myeloproliferative disorders are a group of diseases morphologically linked by terminal myeloid cell expansion that frequently evolve from one clinical phenotype to another and eventually progress to acute myeloid leukemia. Diagnostic criteria for the Philadelphia chromosome–negative myeloproliferative neoplasms (MPNs) have been established by the World Health Organization and they are recognized as blood cancers. MPNs have a complex and incompletely understood pathogenesis that includes systemic inflammation, clonal hematopoiesis, and constitutive activation of the JAK-STAT pathway. Complications, such as thrombosis and progression to overt forms of myelofibrosis and acute leukemia, contribute significantly to morbidity and mortality of patients with MPN.

Original languageEnglish
Pages (from-to)159-176
Number of pages18
JournalHematology/Oncology Clinics of North America
Volume35
Issue number2
DOIs
StatePublished - Apr 2021

Keywords

  • Diagnostic criteria
  • Essential thrombocythemia
  • History
  • Myelofibrosis
  • Myeloproliferative neoplasms
  • Polycythemia vera

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