Overview of evolving strategies incorporating prostate-specific membrane antigen as target for therapy

M. C. Gong; S. S. Chang; F. Watt; D. S. O'Keefe; D. J. Bacich; A. Uchida; N. H. Bander; V. E. Reuter; P. B. Gaudin; P. L. Molloy; M. Sadelian; W. D.W. Heston; S. Howell; W. Sakr; D. Bostwick; N. Bruchovsky; M. Garnick; N. Stone; M. Garzotto

Overview of evolving strategies incorporating prostate-specific membrane antigen as target for therapy

M. C. Gong, S. S. Chang, F. Watt, D. S. O'Keefe, D. J. Bacich, A. Uchida, N. H. Bander, V. E. Reuter, P. B. Gaudin, P. L. Molloy, M. Sadelian, W. D.W. Heston, S. Howell, W. Sakr, D. Bostwick, N. Bruchovsky, M. Garnick, N. Stone, M. Garzotto

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Prostate-specific membrane antigen (PSMA) is a potential target in prostate cancer patients because it is very highly expressed and because it has been reported to be upregulated by androgen deprivation. This overview addresses the expression of the PSMA gene in terms of the promoter and enhancer and how that may play a role in gene therapy. We also review PSMA as a target for antibodies for imaging and treatment and the development of a novel hybrid T-cell receptor that combines the specificity of anti-PSMA antibodies with that of T-cell receptor activation when introduced into primary lymphocytes by retroviral-mediated gene transfer. We also discuss our recent findings on the expression of a PSMA-like gene and how that understanding allows specific targeting of PSMA.

Original language	English
Pages (from-to)	217-223
Number of pages	7
Journal	Molecular Urology
Volume	4
Issue number	3
State	Published - 2000
Externally published	Yes

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Gong, M. C., Chang, S. S., Watt, F., O'Keefe, D. S., Bacich, D. J., Uchida, A., Bander, N. H., Reuter, V. E., Gaudin, P. B., Molloy, P. L., Sadelian, M., Heston, W. D. W., Howell, S., Sakr, W., Bostwick, D., Bruchovsky, N., Garnick, M., Stone, N., & Garzotto, M. (2000). Overview of evolving strategies incorporating prostate-specific membrane antigen as target for therapy. Molecular Urology, 4(3), 217-223.

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title = "Overview of evolving strategies incorporating prostate-specific membrane antigen as target for therapy",

abstract = "Prostate-specific membrane antigen (PSMA) is a potential target in prostate cancer patients because it is very highly expressed and because it has been reported to be upregulated by androgen deprivation. This overview addresses the expression of the PSMA gene in terms of the promoter and enhancer and how that may play a role in gene therapy. We also review PSMA as a target for antibodies for imaging and treatment and the development of a novel hybrid T-cell receptor that combines the specificity of anti-PSMA antibodies with that of T-cell receptor activation when introduced into primary lymphocytes by retroviral-mediated gene transfer. We also discuss our recent findings on the expression of a PSMA-like gene and how that understanding allows specific targeting of PSMA.",

author = "Gong, {M. C.} and Chang, {S. S.} and F. Watt and O'Keefe, {D. S.} and Bacich, {D. J.} and A. Uchida and Bander, {N. H.} and Reuter, {V. E.} and Gaudin, {P. B.} and Molloy, {P. L.} and M. Sadelian and Heston, {W. D.W.} and S. Howell and W. Sakr and D. Bostwick and N. Bruchovsky and M. Garnick and N. Stone and M. Garzotto",

year = "2000",

language = "English",

volume = "4",

pages = "217--223",

journal = "Molecular Urology",

issn = "1091-5362",

publisher = "Mary Ann Liebert Inc.",

number = "3",

}

Gong, MC, Chang, SS, Watt, F, O'Keefe, DS, Bacich, DJ, Uchida, A, Bander, NH, Reuter, VE, Gaudin, PB, Molloy, PL, Sadelian, M, Heston, WDW, Howell, S, Sakr, W, Bostwick, D, Bruchovsky, N, Garnick, M, Stone, N & Garzotto, M 2000, 'Overview of evolving strategies incorporating prostate-specific membrane antigen as target for therapy', Molecular Urology, vol. 4, no. 3, pp. 217-223.

TY - JOUR

T1 - Overview of evolving strategies incorporating prostate-specific membrane antigen as target for therapy

AU - Gong, M. C.

AU - Chang, S. S.

AU - Watt, F.

AU - O'Keefe, D. S.

AU - Bacich, D. J.

AU - Uchida, A.

AU - Bander, N. H.

AU - Reuter, V. E.

AU - Gaudin, P. B.

AU - Molloy, P. L.

AU - Sadelian, M.

AU - Heston, W. D.W.

AU - Howell, S.

AU - Sakr, W.

AU - Bostwick, D.

AU - Bruchovsky, N.

AU - Garnick, M.

AU - Stone, N.

AU - Garzotto, M.

PY - 2000

Y1 - 2000

N2 - Prostate-specific membrane antigen (PSMA) is a potential target in prostate cancer patients because it is very highly expressed and because it has been reported to be upregulated by androgen deprivation. This overview addresses the expression of the PSMA gene in terms of the promoter and enhancer and how that may play a role in gene therapy. We also review PSMA as a target for antibodies for imaging and treatment and the development of a novel hybrid T-cell receptor that combines the specificity of anti-PSMA antibodies with that of T-cell receptor activation when introduced into primary lymphocytes by retroviral-mediated gene transfer. We also discuss our recent findings on the expression of a PSMA-like gene and how that understanding allows specific targeting of PSMA.

AB - Prostate-specific membrane antigen (PSMA) is a potential target in prostate cancer patients because it is very highly expressed and because it has been reported to be upregulated by androgen deprivation. This overview addresses the expression of the PSMA gene in terms of the promoter and enhancer and how that may play a role in gene therapy. We also review PSMA as a target for antibodies for imaging and treatment and the development of a novel hybrid T-cell receptor that combines the specificity of anti-PSMA antibodies with that of T-cell receptor activation when introduced into primary lymphocytes by retroviral-mediated gene transfer. We also discuss our recent findings on the expression of a PSMA-like gene and how that understanding allows specific targeting of PSMA.

UR - http://www.scopus.com/inward/record.url?scp=0033756266&partnerID=8YFLogxK

M3 - Article

C2 - 11062377

AN - SCOPUS:0033756266

SN - 1091-5362

VL - 4

SP - 217

EP - 223

JO - Molecular Urology

JF - Molecular Urology

IS - 3

ER -

Overview of evolving strategies incorporating prostate-specific membrane antigen as target for therapy

Abstract

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