Overall and cause-specific mortality in a cohort of home-/bisexual men, injecting drug users, and female partners of HIV-infected men

W. Kenneth Poole, William Fulkerson, Yu Lou, Paul Kvale, Philip C. Hopewell, Robert Hirschtick, Jeffrey Glassroth, Mark Rosen, Bonita Mangura, Jeanne Wallace, Norman Markowitz

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Objective: To study the overall and cause-specific HIV-related mortality in a cohort of HIV-seropositive subjects according to transmission category, race/ethnicity, sex and severity of immunosuppression. Design: A cohort of 1129 HIV-seropositive homo-/bisexual men, injecting drug users, and female partners of HIV-infected men were enrolled at six centers in San Francisco, Los Angeles, Chicago, Newark, Detroit and New York between 1 November 1988 and 1 November 1989. Subjects were evaluated every 6 months at least until 31 March 1994. Methods: The analyses of overall mortality for the subgroups of interest were performed with Kaplan-Meier plots and Cox proportional hazards models. Cause-specific analyses were performed on the primary cause of death using rates per 100 person-years of exposure. Results and Conclusions: Baseline severity of immunosuppression is the strongest predictor of mortality. There were no statistically significant differences in overall HIV-related mortality among transmission categories, race/ethnicity groups or sexes. There were differences, however, in cause-specific mortality among the different risk groups.

Original languageEnglish
Pages (from-to)1257-1264
Number of pages8
JournalAIDS
Volume10
Issue number11
DOIs
StatePublished - 1996
Externally publishedYes

Keywords

  • AIDS
  • Cause-specific mortality
  • HIV
  • HIV risk groups
  • Mortality
  • Survival analysis

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