@article{3109b0d7fcdf4d8ab270eda8bcf07735,
title = "Over-expression of Flt3 induces NF-κB pathway and increases the expression of IL-6",
abstract = "Activating mutations or over-expression of the Flt3 is prevalent in acute myeloblastic leukemia (AML), associated with activation of Ras/MAP kinase and other signaling pathways. In this study, we addressed the role of Flt3 in the activation of nuclear factor-kappa B (NF-κB), which is a target molecule of these kinase pathways. In BaF3 cells stably expressing Flt3, a NF-κB-responsive reporter was upregulated and its target gene, IL-6, was increased by the involvement of Flt3-ERK/MAPK-NF-κB pathway. Furthermore, we found a modest positive correlation (r = 0.35, p = 0.096) between Flt3 and IL-6 mRNA expression in 24 AML specimens. These results suggest a role of Flt3 over-expression in NF-κB pathway.",
keywords = "AML, Flt3, IL-6, NF-κB",
author = "Shinichiro Takahashi and Hideo Harigae and Ishii, {Keiko Kumura} and Mitsue Inomata and Tohru Fujiwara and Hisayuki Yokoyama and Kenichi Ishizawa and Junichi Kameoka and Licht, {Jonathan D.} and Takeshi Sasaki and Mitsuo Kaku",
note = "Funding Information: Authors thank for Dr. G. Gilliland for providing MSCV-Flt3-GFP plasmid and Dr. H. Schepers for helpful suggestions. We also thank for Drs. M. Yamada, Y. Tohmiya, M. Seki and Y. Okitsu for stimulating discussions. This work is supported in part by Japan Society of Promotion of Science (to S.T.), Kurozumi Medical Foundation (to S.T.), Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan (to H.H., T.S.). ",
year = "2005",
month = aug,
doi = "10.1016/j.leukres.2005.01.008",
language = "English",
volume = "29",
pages = "893--899",
journal = "Leukemia Research",
issn = "0145-2126",
publisher = "Elsevier Ltd.",
number = "8",
}