Outcomes of trabeculectomy with 5-fluorouracil at a Nigerian tertiary hospital

Olusola O. Olawoye, Adeyinka O. Ashaye, Aderonke M. Baiyeroju, Christopher C. Teng, Jeffrey M. Liebmann, Robert Ritch

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Purpose: To report the outcomes of trabeculectomy with adjunctive 5-Fluorouracil (5-FU) at a Nigerian tertiary hospital. Methods: In this prospective study, all patients with glaucoma undergoing trabeculectomy with 5-FU at the University College Hospital, Ibadan, Nigeria, from June 2009 to May 2010 were enrolled. Each patient had a complete ophthalmic evaluation. Intraocular pressure (IOP), visual acuity (VA) and complications post-trabeculectomy were assessed at one year. Success of the procedure was defined as complete when no additional medications were required to achieve an IOP of ≤18mmHg, or qualified when additional medications were required to achieve the same goal. Results: A total of 47 eyes of 31 patients with mean age of 48.9±19.6 (range 14-77; median 52) years including 21 (67.7%) male subjects underwent trabeculectomy with 5-FU. Mean presenting IOP was 31.8±12.2 mmHg. Mean deviation (MD) on Humphrey visual fields was -15.9±9.7dB with the majority of the patients (18 subjects 58.1%) presenting with advanced glaucoma based on MD worse than -12dB and severe glaucomatous optic neuropathy (cup to disc ratio of 0.9-1.0). At 1 year postoperatively, 95.1% achieved qualified success while 83% had complete success. Conclusion: This prospective study adds to the existing knowledge that trabeculectomy with 5-FU is effective at controlling IOP in Nigerian patients.

Original languageEnglish
Pages (from-to)126-133
Number of pages8
JournalJournal of Ophthalmic and Vision Research
Volume8
Issue number2
StatePublished - 2013
Externally publishedYes

Keywords

  • 5-fluorouracil
  • Nigeria
  • Trabeculectomy

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