Outcomes of intracytoplasmic sperm injection cycles for complete teratozoospermia: A case-control study Using Paired Sibling Oocytes

Nigel Pereira, Queenie V. Neri, Jovana P. Lekovich, Steven D. Spandorfer, Gianpiero D. Palermo, Zev Rosenwaks

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Objective. To investigate the outcomes of intracytoplasmic sperm injection (ICSI) cycles where sibling oocytes from a single donor were split between two recipients based on strict sperm morphology. Methods. Retrospective cohort study. All ICSI cycles had one donor's oocytes split between two recipients in a 1: 1 ratio based on strict sperm morphology, that is, one male partner had morphology of 0% and the other had morphology of >1%. Fertilization, positive hCG, clinical pregnancy, spontaneous miscarriage, and live birth rates of the aforementioned groups were compared. Results. The baseline characteristics of the two groups (n=103), including semen parameters of the male partners, were comparable. There was no difference in the fertilization rates when comparing the 0% group to the >1% group (78.7% versus 81.6%; P=0.66). The overall positive hCG, clinical pregnancy, spontaneous miscarriage, and live birth rates for the 0% group were 61.2%, 49.5%, 10.7%, and 38.8%, respectively. The corresponding rates in the >1% group were positive hCG (63.1%), clinical pregnancy (55.3%), spontaneous miscarriage (7.77%), and live birth (46.6%). Conclusions. The fertilization and pregnancy outcomes of ICSI cycles for strict sperm morphology of 0% versus morphology of >1% are equivalent. These results can provide reassurance to couples undergoing ICSI for severe teratospermia.

Original languageEnglish
Article number470819
JournalBioMed Research International
Volume2015
DOIs
StatePublished - 2015
Externally publishedYes

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