Osteoporosis: An unusual presentation of childhood Crohn's disease

M. Thearle, M. Horlick, J. P. Bilezikian, J. Levy, J. M. Gertner, L. S. Levine, M. Harbison, W. Berdon, S. E. Oberfield

Research output: Contribution to journalArticlepeer-review

90 Scopus citations


Osteoporosis is known to be associated with Crohn's disease. We report a 12-yr-old boy without a history of steroid use, in whom severe osteoporosis and multiple collapsed vertebrae were the presenting manifestations of Crohn's disease. After treatment of the Crohn's disease, he resumed normal growth and progressed through puberty. Concomitantly, he demonstrated a substantial recovery of vertebral bone mineral density and structure. Possible pathophysiological mechanisms underlying the osteoporosis and the subsequent improvement in bone density are discussed.

Original languageEnglish
Pages (from-to)2122-2126
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Issue number6
StatePublished - 2000
Externally publishedYes


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